Overview

  • Product nameAnti-PRPF31 antibody
    See all PRPF31 primary antibodies
  • Description
    Rabbit polyclonal to PRPF31
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthesized peptide derived from an internal region of human PRPF31

  • Positive control
    • Extracts from HeLa cells

Properties

Applications

Our Abpromise guarantee covers the use of ab69577 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 55 kDa (predicted molecular weight: 55 kDa).
ELISA 1/5000.

Target

  • FunctionInvolved in pre-mRNA splicing. Required for U4/U6.U5 tri-snRNP formation.
  • Tissue specificityUbiquitously expressed.
  • Involvement in diseaseDefects in PRPF31 are the cause of retinitis pigmentosa type 11 (RP11) [MIM:600138]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP11 inheritance is autosomal dominant.
  • Sequence similaritiesBelongs to the PRP31 family.
    Contains 1 Nop domain.
  • DomainInteracts with the snRNP via the Nop domain.
    The coiled coil domain is formed by two non-contiguous helices.
  • Cellular localizationNucleus speckle. Nucleus > Cajal body. Predominantly found in speckles and in Cajal bodies.
  • Information by UniProt
  • Database links
  • Alternative names
    • DKFZp566J153 antibody
    • hPrp 31 antibody
    • hPrp31 antibody
    • NY BR 99 antibody
    • Pre mRNA processing factor 31 antibody
    • Pre mRNA processing factor 31 homolog (yeast) antibody
    • Pre mRNA processing factor 31 homolog antibody
    • Pre-mRNA-processing factor 31 antibody
    • Precursor mRNA-processing factor 31, S. cerevisiae, homolog of antibody
    • Protein 61K antibody
    • PRP 31 antibody
    • PRP31 antibody
    • PRP31 pre mRNA processing factor 31 homolog (yeast) antibody
    • PRP31 pre mRNA processing factor 31 homolog antibody
    • PRP31_HUMAN antibody
    • PRPF 31 antibody
    • prpf31 antibody
    • RP 11 antibody
    • RP11 antibody
    • Serologically defined breast cancer antigen NY BR 99 antibody
    • Serologically defined breast cancer antigen NY-BR-99 antibody
    • SNRNP61 antibody
    • U4/U6 small nuclear ribonucleoprotein Prp31 antibody
    • U4/U6 snRNP 61 kDa protein antibody
    see all

Anti-PRPF31 antibody images

  • All lanes : Anti-PRPF31 antibody (ab69577) at 1/500 dilution

    Lane 1 : extracts from HeLa cells, without immunising peptide
    Lane 2 : extracts from HeLa cells, with immunising peptide

    Lysates/proteins at 5 µg per lane.


    Predicted band size : 55 kDa
    Observed band size : 55 kDa
    Additional bands at : 33 kDa. We are unsure as to the identity of these extra bands.

References for Anti-PRPF31 antibody (ab69577)

ab69577 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"