Overview

  • Product nameAnti-PRUNE antibody
    See all PRUNE primary antibodies
  • Description
    Rabbit polyclonal to PRUNE
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 367-397 of Human PRUNE

  • Positive control
    • Jurkat cell lysate. Human prostate carcinoma.

Properties

Applications

Our Abpromise guarantee covers the use of ab102945 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 50 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionPhosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1.
  • Tissue specificityUbiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas.
  • Sequence similaritiesBelongs to the PPase class C family. Prune subfamily.
  • Cellular localizationCytoplasm. Nucleus. Cell junction > focal adhesion. In some transfected cells a nuclear staining is also observed.
  • Information by UniProt
  • Database links
  • Alternative names
    • DRES-17 antibody
    • DRES17 antibody
    • Drosophila-related expressed sequence 17 antibody
    • hPrune antibody
    • HTcD37 antibody
    • Protein prune homolog antibody
    • PRUNE antibody
    • Prune homolog antibody
    • PRUNE like protein antibody
    • PRUNE_HUMAN antibody
    • TcD37 homolog antibody
    see all

Anti-PRUNE antibody images

  • Anti-PRUNE antibody (ab102945) at 1/100 dilution + Jurkat cell lysate at 35 µg

    Predicted band size : 50 kDa
  • ab102945, at 1/50 dilution, staining PRUNE in formalin fixed and paraffin embedded Human prostate carcinoma by immunohistochemistry.

References for Anti-PRUNE antibody (ab102945)

ab102945 has not yet been referenced specifically in any publications.

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