Overview

  • Product namePSB 11 hydrochloride
  • Description
    Potent, selective, competitive human A3 receptor antagonist
  • Alternative names
    • PSB11 hydrochloride
  • Biological description

    Potent, selective, competitive human A3 receptor antagonist (Ki values are 2.3 nM and 10 μM for human and rat A3 receptors, respectively), Antagonises human A1 and A2A receptors. Shows inverse agonist effects in the [35S]GTPγS binding assay. Shows anti-inflammatory effects.

  • Purity> 99%

Properties

  • Chemical name(R)-8-Ethyl-3,4,7,8-tetrahydro-4-methyl-2-phenyl-5H-imidazo[2,1-i]purin-5-one hydrochloride
  • Molecular weight331.80
  • Chemical structureChemical Structure
  • Molecular formulaC16H17N5O.HCl
  • CAS Number453591-58-7
  • PubChem identifier16759152
  • Storage instructionsStore at -20°C. Store at -20°C long term. Store In the Dark. Store under Desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overviewSoluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESCl.O=C2N(C)c3nc(nc3C1=N[C@@H](CN12)CC)c4ccccc4
  • Source

    Synthetic

    References for PSB 11 hydrochloride (ab120995)

    This product has been referenced in:
    • Sekharan S  et al. Spectral tuning of ultraviolet cone pigments: an interhelical lock mechanism. J Am Chem Soc 135:19064-7 (2013). Read more (PubMed: 24295328) »
    • Kim SK  et al. Docking studies of agonists and antagonists suggest an activation pathway of the A3 adenosine receptor. J Mol Graph Model 25:562-77 (2006). Read more (PubMed: 16793299) »
    • Ozola V  et al. 2-Phenylimidazo[2,1-i]purin-5-ones: structure-activity relationships and characterization of potent and selective inverse agonists at Human A3 adenosine receptors. Bioorg Med Chem 11:347-56 (2003). Read more (PubMed: 12517430) »
    • Müller CE Medicinal chemistry of adenosine A3 receptor ligands. Curr Top Med Chem 3:445-62 (2003). Read more (PubMed: 12570761) »
    • Müller CE  et al. Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A(2A)- and A(3)-adenosine receptor antagonists. J Med Chem 45:3440-50 (2002). Read more (PubMed: 12139454) »
    • Gao ZG  et al. Selective allosteric enhancement of agonist binding and function at human A3 adenosine receptors by a series of imidazoquinoline derivatives. Mol Pharmacol 62:81-9 (2002). Read more (PubMed: 12065758) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"