Overview

  • Product name
    Anti-PSD93 antibody [N18/30]
    See all PSD93 primary antibodies
  • Description
    Mouse monoclonal [N18/30] to PSD93
  • Specificity
    No cross-reactivity against other MAGUK family members PSD95, SAP97, SAP102 expressed in transfected cells.
  • Tested applications
    Suitable for: WB, IHC-P, IHC-Fr, ICC/IFmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Fusion protein, corresponding to amino acids 1 - 852 of Rat PSD93 (UniProt Q63622).

  • Positive control
    • Rat brain lysate
  • General notes

    The clone number has been updated from S18-30 to N18/30, both clone numbers name the same antibody clone.

     

Properties

Applications

Our Abpromise guarantee covers the use of ab94588 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IHC-P
IHC-Fr
ICC/IF
  • Application notes
    ICC/IF: Use at a concentration of 0.1-1.0µg/mL (perox) or 1.0-10µg/mL (IF).
    IHC-P: Use at a concentration of 0.1-1.0µg/mL (perox) or 1.0-10µg/mL (IF).
    IHC-Fr: Use at a concentration of 0.1-1.0µg/mL (perox) or 1.0-10µg/mL (IF).
    WB: Use at a concentration of 1 - 10 µg/ml. Predicted molecular weight: 97 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses.
    • Sequence similarities
      Belongs to the MAGUK family.
      Contains 1 guanylate kinase-like domain.
      Contains 3 PDZ (DHR) domains.
      Contains 1 SH3 domain.
    • Domain
      An N-terminally truncated L27 domain is predicted in isoform 2 at positions 1 through 27.
    • Post-translational
      modifications
      Palmitoylation of isoform 1 is not required for targeting to postsynaptic density.
    • Cellular localization
      Cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Membrane. Cell projection, axon. Concentrated in soma and postsynaptic density of a subset of neurons.
    • Information by UniProt
    • Database links
    • Alternative names
      • Channel associated protein of synapse 110 antibody
      • Channel associated protein of synapses 110kD antibody
      • Channel-associated protein of synapse-110 antibody
      • Chapsyn 110 antibody
      • Chapsyn-110 antibody
      • Chapsyn110 antibody
      • Discs, large homolog 2 (Drosophila) antibody
      • Disks large homolog 2 antibody
      • DKFZp781D1854 antibody
      • DKFZp781E0954 antibody
      • Dlg 2 antibody
      • dlg2 antibody
      • DLG2_HUMAN antibody
      • Dlgh 2 antibody
      • Dlgh2 antibody
      • FLJ37266 antibody
      • Gm1197 antibody
      • MGC131811 antibody
      • Postsynaptic density protein PSD 93 antibody
      • Postsynaptic density protein PSD-93 antibody
      • Postsynaptic density protein PSD93 antibody
      • PSD 93 antibody
      • PSD93 antibody
      see all

    Images



    • Predicted band size : 97 kDa
      Western blot detection of PSD93 in Rat brain membrane lysates using ab94588 at 1:1000 dilution.

    References

    ab94588 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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