Overview

  • Product nameAnti-PSD95 (phospho S418) antibody [EPR2618Y]
    See all PSD95 primary antibodies
  • Description
    Rabbit monoclonal [EPR2618Y] to PSD95 (phospho S418)
  • Tested applicationsSuitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC,IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A synthetic phospho-peptide corresponding to residues surrounding serine 418 of human PSD95.

  • Positive control
    • Rat brain tissue cell lysate.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Properties

Applications

Our Abpromise guarantee covers the use of ab76127 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500. Predicted molecular weight: 95 kDa.
  • Application notesIs unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • Target

    • FunctionInteracts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.
    • Tissue specificityBrain.
    • Sequence similaritiesBelongs to the MAGUK family.
      Contains 1 guanylate kinase-like domain.
      Contains 3 PDZ (DHR) domains.
      Contains 1 SH3 domain.
    • DomainThe PDZ domain 3 mediates interaction with ADR1B.
      The L27 domain near the N-terminus of isoform 2 is required for HGS/HRS-dependent targeting to postsynaptic density.
    • Post-translational
      modifications
      Palmitoylation of isoform 1 is required for targeting to postsynaptic density.
    • Cellular localizationCell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, axon. Cell junction, synapse. High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells.
    • Information by UniProt
    • Database links
    • Alternative names
      • Discs large homolog 4 antibody
      • Disks large homolog 4 antibody
      • DLG 4 antibody
      • Dlg4 antibody
      • DLG4_HUMAN antibody
      • FLJ97752 antibody
      • FLJ98574 antibody
      • Human post synaptic density protein 95 antibody
      • Post synaptic density protein 95 antibody
      • Postsynaptic density protein 95 antibody
      • PSD 95 antibody
      • PSD-95 antibody
      • PSD95 antibody
      • SAP 90 antibody
      • SAP-90 antibody
      • SAP90 antibody
      • Synapse associated protein 90 antibody
      • Synapse-associated protein 90 antibody
      • Tax interaction protein 15 antibody
      see all

    Anti-PSD95 (phospho S418) antibody [EPR2618Y] images

    • All lanes : Anti-PSD95 (phospho S418) antibody [EPR2618Y] (ab76127) at 1/500 dilution

      Lane 1 : Rat brain tissue cell lysates, untreated
      Lane 2 : Rat brain tissue cell lysates, treated with AP

      Lysates/proteins at 10 µg per lane.

      Secondary
      goat anti-rabbit-HRP at 1/1000 dilution
      Developed using the ECL technique

      Predicted band size : 95 kDa
      Observed band size : 95 kDa

    References for Anti-PSD95 (phospho S418) antibody [EPR2618Y] (ab76127)

    This product has been referenced in:
    • Zhu YC  et al. Palmitoylation-dependent CDKL5-PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development. Proc Natl Acad Sci U S A 110:9118-23 (2013). Read more (PubMed: 23671101) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"