Overview

  • Product name
  • Description
    Chicken polyclonal to PSF2
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Full length native protein (purified) (Human) PSF2

  • Positive control
    • E coli derived fusion protein.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer
    Azide free.
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgY
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab37683 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2000. Predicted molecular weight: 21 kDa. We recommend using about 2.5 ug of positive control protein in the colorimetric method, and about 10x less for ECL detection.
ICC/IF Use at an assay dependent dilution. PubMed: 20571081

Target

  • Function
    The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.
  • Sequence similarities
    Belongs to the GINS2/PSF2 family.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • DNA replication complex GINS protein PSF2 antibody
    • GINS complex subunit 2 (Psf2 homolog) antibody
    • GINS complex subunit 2 antibody
    • gins2 antibody
    • HSPC037 antibody
    • Pfs2 antibody
    • PSF2 antibody
    • PSF2_HUMAN antibody
    see all

Images

References

This product has been referenced in:
  • Tumini E  et al. Physical and functional crosstalk between Fanconi anemia core components and the GINS replication complex. DNA Repair (Amst) 10:149-58 (2011). WB ; Human . Read more (PubMed: 21109493) »
  • Cohen SM  et al. BRG1 co-localizes with DNA replication factors and is required for efficient replication fork progression. Nucleic Acids Res 38:6906-19 (2010). ICC/IF ; Mouse . Read more (PubMed: 20571081) »

See all 3 Publications for this product

Customer reviews and Q&As

Thank you for your inquiry; the source of this antibody traditionally uses the fusion proteins as testing positive controls, therefore we do not know how the antibody performs on endogenous protein I'm afraid.I can confirm that they have loaded between...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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