Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • AccessionP28074
    • SequenceWIRVSSDNVADLHDKYS
    • Amino acids243 to 259

Associated products

Specifications

Our Abpromise guarantee covers the use of ab4946 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLiquid
  • Additional notes


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human proteasome PSMB5, catalog ab3330. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

General Info

  • Alternative names
    • DKFZp459C139
    • EC 3.4.25.1
    • LMPX
    • Macropain epsilon chain
    • MB1
    • MGC104214
    • MGC118075
    • MGC134464
    • Multicatalytic endopeptidase complex epsilon chain
    • Proteasome (prosome, macropain) subunit, beta type, 5
    • Proteasome beta 5 subunit
    • Proteasome catalytic subunit 3
    • Proteasome chain 6
    • Proteasome epsilon chain
    • Proteasome subunit beta type-5
    • Proteasome subunit MB1
    • Proteasome subunit X
    • Proteasome subunit, beta type, 5
    • Proteasome subunit, beta-5
    • PSB5_HUMAN
    • PSMB5
    • PSX large multifunctional protease X
    • X
    see all
  • FunctionThe proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the chymotrypsin-like activity of the proteasome and is one of the principal target of the proteasome inhibitor bortezomib. May catalyze basal processing of intracellular antigens. Plays a role in the protection against oxidative damage throught the Nrf2-ARE pathway.
  • Sequence similaritiesBelongs to the peptidase T1B family.
  • Cellular localizationCytoplasm. Nucleus.
  • Information by UniProt

References for PSMB5 peptide (ab4946)

ab4946 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab4946.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"