Overview

  • Product nameAnti-PSMC3IP antibody
    See all PSMC3IP primary antibodies
  • Description
    Mouse polyclonal to PSMC3IP
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length PSMC3IP protein (Human) (NP_057640)

  • Positive control
    • PSMC3IP transfected 293T cell lysate

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: Whole serum
  • PurityWhole antiserum
  • ClonalityPolyclonal
  • IsotypeIgG

Applications

Our Abpromise guarantee covers the use of ab68786 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 30 kDa (predicted molecular weight: 25 kDa).

Target

  • FunctionPlays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors.
  • Tissue specificityHighly expressed in testis and colon.
  • Involvement in diseaseOvarian dysgenesis 3 (ODG3) [MIM:614324]: A disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Sequence similaritiesBelongs to the HOP2 family.
  • Post-translational
    modifications
    PTM: Phosphorylated by PKA, PKC and MAPK.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • DBD interacting antibody
    • GT198 antibody
    • Homologous pairing protein 2 homolog antibody
    • Homologous-pairing protein 2 homolog antibody
    • HOP2 antibody
    • HOP2_HUMAN antibody
    • Nuclear receptor coactivator GT198 antibody
    • Proteasome 26S ATPase subunit 3 interacting protein antibody
    • Proteasome 26S ATPase subunit 3-interacting protein antibody
    • PSMC3 interacting protein antibody
    • PSMC3-interacting protein antibody
    • Psmc3ip antibody
    • Tat binding protein 1-interacting protein antibody
    • Tat-binding protein 1-interacting protein antibody
    • TBP-1-interacting protein antibody
    • TBP1 interacting protein antibody
    • TBPIP antibody
    see all

Anti-PSMC3IP antibody images

  • All lanes : Anti-PSMC3IP antibody (ab68786) at 1/500 dilution

    Lane 1 : PSMC3IP transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate secondary antibody at 1/5000 dilution
    Developed using the ECL technique

    Predicted band size : 25 kDa
    Observed band size : 30 kDa (why is the actual band size different from the predicted?)

References for Anti-PSMC3IP antibody (ab68786)

ab68786 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"