Overview

  • Product nameAnti-PSMC3IP antibody
    See all PSMC3IP primary antibodies
  • Description
    Rabbit polyclonal to PSMC3IP
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Goat, Horse, Chicken, Cow, Cat, Dog, Pig, Zebrafish
  • Immunogen

    Synthetic peptide derived from within residues: PEEKEQVYRE RQKYCKEWRK RKRMATELSD AILEGYPKSK KQFFEEVGIE , corresponding to internal sequence amino acids 143-192 of Human PSMC3IP (NP_037422)

  • Positive control
    • 721_B cell lysate

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG

Applications

Our Abpromise guarantee covers the use of ab82772 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 24 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

Titre using peptide based assay: 1/1562500.

Target

  • FunctionPlays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors.
  • Tissue specificityHighly expressed in testis and colon.
  • Involvement in diseaseOvarian dysgenesis 3 (ODG3) [MIM:614324]: A disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Sequence similaritiesBelongs to the HOP2 family.
  • Post-translational
    modifications
    PTM: Phosphorylated by PKA, PKC and MAPK.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • DBD interacting antibody
    • GT198 antibody
    • Homologous pairing protein 2 homolog antibody
    • Homologous-pairing protein 2 homolog antibody
    • HOP2 antibody
    • HOP2_HUMAN antibody
    • Nuclear receptor coactivator GT198 antibody
    • Proteasome 26S ATPase subunit 3 interacting protein antibody
    • Proteasome 26S ATPase subunit 3-interacting protein antibody
    • PSMC3 interacting protein antibody
    • PSMC3-interacting protein antibody
    • Psmc3ip antibody
    • Tat binding protein 1-interacting protein antibody
    • Tat-binding protein 1-interacting protein antibody
    • TBP-1-interacting protein antibody
    • TBP1 interacting protein antibody
    • TBPIP antibody
    see all

Anti-PSMC3IP antibody images

  • Anti-PSMC3IP antibody (ab82772) at 1 µg/ml + 721_B cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 24 kDa
    Observed band size : 24 kDa
    Additional bands at : 28 kDa,55 kDa. We are unsure as to the identity of these extra bands.

References for Anti-PSMC3IP antibody (ab82772)

ab82772 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab82772.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"