Overview

  • Product nameAnti-PSME3 antibody [4B2-C2-G4]
    See all PSME3 primary antibodies
  • Description
    Mouse monoclonal [4B2-C2-G4] to PSME3
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length Human PSME3 (NM_005789).

  • Positive control
    • HepG2, Jurkat and K562 whole cell lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab106213 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/2000. Predicted molecular weight: 30 kDa.
ELISA 1/5000 - 1/20000.

Target

  • FunctionSubunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a donut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.
  • Sequence similaritiesBelongs to the PA28 family.
  • DomainThe C-terminal sequences affect heptamer stability and proteasome affinity.
  • Post-translational
    modifications
    Phosphorylated by MAP3K3.
  • Cellular localizationNucleus. Cytoplasm. Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase.
  • Information by UniProt
  • Database links
  • Alternative names
    • 11S regulator complex gamma subunit antibody
    • 11S regulator complex subunit gamma antibody
    • Activator of multicatalytic protease subunit 3 antibody
    • Ki antibody
    • Ki antigen antibody
    • Ki nuclear autoantigen antibody
    • Ki, PA28 gamma antibody
    • PA28 gamma antibody
    • PA28g antibody
    • PA28gamma antibody
    • Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) antibody
    • Proteasome (prosome, macropain) activator subunit 3 antibody
    • Proteasome activator 28 gamma antibody
    • Proteasome activator 28 subunit gamma antibody
    • Proteasome activator complex subunit 3 antibody
    • Proteasome activator subunit 3 antibody
    • PSME3 antibody
    • PSME3_HUMAN antibody
    • REG GAMMA antibody
    • REG-gamma antibody
    see all

Anti-PSME3 antibody [4B2-C2-G4] images

  • All lanes : Anti-PSME3 antibody [4B2-C2-G4] (ab106213) at 1/1000 dilution

    Lane 1 : HepG2 whole cell lysate
    Lane 2 : Jurkat whole cell lysate
    Lane 3 : K562 whole cell lysate

    Lysates/proteins at 40 µg per lane.


    Predicted band size : 30 kDa
    Observed band size : 33 kDa (why is the actual band size different from the predicted?)

References for Anti-PSME3 antibody [4B2-C2-G4] (ab106213)

ab106213 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"