Overview

  • Product name
  • Description
    Rabbit polyclonal to PSME3
  • Specificity
    Detects recombinant human proteasome activator 11S REG gamma subunit.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Chicken, Pig, Cynomolgus monkey
  • Immunogen

    Synthetic peptide corresponding to Human PSME3 aa 1-14.
    Sequence:

    MASLLKVDQEVKLK


    (Peptide available as ab4950)

Properties

Applications

Our Abpromise guarantee covers the use of ab3334 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 28 kDa (predicted molecular weight: 29 kDa).Can be blocked with PSME3 peptide (ab4950).

Target

  • Function
    Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a donut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.
  • Sequence similarities
    Belongs to the PA28 family.
  • Domain
    The C-terminal sequences affect heptamer stability and proteasome affinity.
  • Post-translational
    modifications
    Phosphorylated by MAP3K3.
  • Cellular localization
    Nucleus. Cytoplasm. Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase.
  • Information by UniProt
  • Database links
  • Alternative names
    • 11S regulator complex gamma subunit antibody
    • 11S regulator complex subunit gamma antibody
    • Activator of multicatalytic protease subunit 3 antibody
    • Ki antibody
    • Ki antigen antibody
    • Ki nuclear autoantigen antibody
    • Ki, PA28 gamma antibody
    • PA28 gamma antibody
    • PA28g antibody
    • PA28gamma antibody
    • Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) antibody
    • Proteasome (prosome, macropain) activator subunit 3 antibody
    • Proteasome activator 28 gamma antibody
    • Proteasome activator 28 subunit gamma antibody
    • Proteasome activator complex subunit 3 antibody
    • Proteasome activator subunit 3 antibody
    • PSME3 antibody
    • PSME3_HUMAN antibody
    • REG GAMMA antibody
    • REG-gamma antibody
    see all

Images



  • Predicted band size : 29 kDa

    Western blot detection of recombinant Human PSME3 using ab3334.

References

ab3334 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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