Overview

  • Product name
    Anti-PSME3 antibody - C-terminal
    See all PSME3 primary antibodies
  • Description
    Rabbit polyclonal to PSME3 - C-terminal
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide selected from the C-terminal region of Human PSME3 conjugated to KLH (NP_005780).

  • Positive control
    • Ramos cell line lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab91542 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notes
    ELISA: 1/1000.
    WB: 1/100 - 1/500. Predicted molecular weight: 30 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a donut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.
    • Sequence similarities
      Belongs to the PA28 family.
    • Domain
      The C-terminal sequences affect heptamer stability and proteasome affinity.
    • Post-translational
      modifications
      Phosphorylated by MAP3K3.
    • Cellular localization
      Nucleus. Cytoplasm. Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase.
    • Information by UniProt
    • Database links
    • Alternative names
      • 11S regulator complex gamma subunit antibody
      • 11S regulator complex subunit gamma antibody
      • Activator of multicatalytic protease subunit 3 antibody
      • Ki antibody
      • Ki antigen antibody
      • Ki nuclear autoantigen antibody
      • Ki, PA28 gamma antibody
      • PA28 gamma antibody
      • PA28g antibody
      • PA28gamma antibody
      • Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) antibody
      • Proteasome (prosome, macropain) activator subunit 3 antibody
      • Proteasome activator 28 gamma antibody
      • Proteasome activator 28 subunit gamma antibody
      • Proteasome activator complex subunit 3 antibody
      • Proteasome activator subunit 3 antibody
      • PSME3 antibody
      • PSME3_HUMAN antibody
      • REG GAMMA antibody
      • REG-gamma antibody
      see all

    Images

    • Anti-PSME3 antibody - C-terminal (ab91542) at 1/100 dilution + Ramos cell line lysates at 35 µg

      Predicted band size : 30 kDa

    References

    ab91542 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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