Overview

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab4950 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Additional notes


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human proteasome activator 11S REG gamma, catalog ab3334. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

General Info

  • Alternative names
    • 11S regulator complex gamma subunit
    • 11S regulator complex subunit gamma
    • Activator of multicatalytic protease subunit 3
    • Ki
    • Ki antigen
    • Ki nuclear autoantigen
    • Ki, PA28 gamma
    • PA28 gamma
    • PA28g
    • PA28gamma
    • Proteasome (prosome, macropain) activator subunit 3
    • Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
    • Proteasome activator 28 gamma
    • Proteasome activator 28 subunit gamma
    • Proteasome activator complex subunit 3
    • Proteasome activator subunit 3
    • PSME3
    • PSME3_HUMAN
    • REG GAMMA
    • REG-gamma
    see all
  • Function
    Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a donut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.
  • Sequence similarities
    Belongs to the PA28 family.
  • Domain
    The C-terminal sequences affect heptamer stability and proteasome affinity.
  • Post-translational
    modifications
    Phosphorylated by MAP3K3.
  • Cellular localization
    Nucleus. Cytoplasm. Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase.
  • Information by UniProt

References

ab4950 has not yet been referenced specifically in any publications.

Publishing research using ab4950? Please let us know so that we can cite the reference in this datasheet.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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