Overview

  • Product name
  • Description
    Rabbit polyclonal to PSPC1
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Recombinant fragment within Human PSPC1 aa 1-176. The exact sequence is proprietary.
    Database link: Q8WXF1

  • Positive control
    • 293T, HeLa and HepG2 whole cell lysates. Rat fore brain and mouse hind brain tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab184123 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/1000.
WB 1/500 - 1/3000. Predicted molecular weight: 59 kDa.

Target

  • Function
    Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers.
  • Tissue specificity
    Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.
  • Sequence similarities
    Belongs to the PSPC family.
    Contains 2 RRM (RNA recognition motif) domains.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization
    Nucleus > nucleolus. Nucleus matrix. Cytoplasm. In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in a RNA-dependent manner. May cycles between paraspeckles and nucleolus. In telophase, when daughter nuclei form, localizes to perinucleolar caps.
  • Information by UniProt
  • Database links
  • Alternative names
    • Paraspeckle component 1 antibody
    • Paraspeckle protein 1 antibody
    • PSP1 antibody
    • Pspc1 antibody
    • PSPC1_HUMAN antibody
    see all

Images

  • All lanes : Anti-PSPC1 antibody (ab184123) at 1/2000 dilution

    Lane 1 : 293T whole cell lysate
    Lane 2 : Hela whole cell lysate
    Lane 3 : HepG2 whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 59 kDa



    7.5% SDS PAGE

  • Immunohistochemical analysis of paraffin-embedded rat fore brain labeling PSPC1 with ab184123 at 1/500 dilution

  • Immunohistochemical analysis of paraffin-embedded mouse hind brain labeling PSPC1 with ab184123 at 1/500 dilution

References

ab184123 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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