Validated using a knockout cell line

Anti-PTEN antibody [Y184] (ab32199)

Publishing research using ab32199? Please let us know so that we can cite the reference in this datasheet.

ab32199 has been referenced in 50 publications.

  • Fan D  et al. MicroRNA 26b promotes colorectal cancer metastasis by downregulating phosphatase and tensin homolog and wingless-type MMTV integration site family member 5A. Cancer Sci 109:354-362 (2018). WB ; Human . PubMed: 29160937
  • Yang N  et al. Epigallocatechin-3-gallate inhibits inflammation and epithelial-mesenchymal transition through the PI3K/AKT pathway via upregulation of PTEN in asthma. Int J Mol Med 41:818-828 (2018). WB ; Mouse . PubMed: 29207033
  • Yan F  et al. Role of miR-21 in the growth and metastasis of human salivary adenoid cystic carcinoma. Mol Med Rep 17:4237-4244 (2018). PubMed: 29328455
  • Choi WH  et al. Microsatellite Alterations and Protein Expression of 5 Major Tumor Suppressor Genes in Gastric Adenocarcinomas. Transl Oncol 11:43-55 (2018). IHC-P ; Human . PubMed: 29172180
  • Chu P  et al. miR-205 regulates the proliferation and invasion of ovarian cancer cells via suppressing PTEN/SMAD4 expression. Oncol Lett 15:7571-7578 (2018). PubMed: 29725462
  • Zhu HY  et al. Long non-coding RNA UCA1 desensitizes breast cancer cells to trastuzumab by impeding miR-18a repression of Yes-associated protein 1. Biochem Biophys Res Commun 496:1308-1313 (2018). WB . PubMed: 29408336
  • Xie Y  et al. Anti-diabetic effect of Alpinia oxyphylla extract on 57BL/KsJ db-/db- mice. Exp Ther Med 13:1321-1328 (2017). WB ; Mouse . PubMed: 28413472
  • Weng M  et al. The E3 ubiquitin ligase NEDD4 is translationally upregulated and facilitates pancreatic cancer. Oncotarget 8:20288-20296 (2017). WB ; Human . PubMed: 28423617
  • Gong Y  et al. Elucidating the mechanism of miRNA-214 in the regulation of gingival carcinoma. Exp Ther Med 13:2544-2550 (2017). PubMed: 28565877
  • Hu J  et al. Tumor grade related expression of neuroglobin is negatively regulated by PPAR? and confers antioxidant activity in glioma progression. Redox Biol 12:682-689 (2017). WB . PubMed: 28410531
  • Yu X  et al. miRNA-21 enhances chemoresistance to cisplatin in epithelial ovarian cancer by negatively regulating PTEN. Oncol Lett 14:1807-1810 (2017). PubMed: 28789414
  • Wang L  et al. Exosomes derived from pancreatic cancer cells induce insulin resistance in C2C12 myotube cells through the PI3K/Akt/FoxO1 pathway. Sci Rep 7:5384 (2017). PubMed: 28710412
  • Guo J  et al. miR-20b promotes cellular proliferation and migration by directly regulating phosphatase and tensin homolog in prostate cancer. Oncol Lett 14:6895-6900 (2017). PubMed: 29163708
  • Shi ZX  et al. Yi-qi-yang-yin-tang increases the sensitivity of KG1a leukemia stem cells to daunorubicin by promoting cell cycle progression and regulating the expression of PTEN, TOPOII and mTOR. Oncol Lett 14:6441-6448 (2017). PubMed: 29163680
  • Dong P  et al. Musashi-2, a novel oncoprotein promoting cervical cancer cell growth and invasion, is negatively regulated by p53-induced miR-143 and miR-107 activation. J Exp Clin Cancer Res 36:150 (2017). PubMed: 29073938
  • Na YS  et al. Establishment and characterization of patient-derived xenograft models of gastrointestinal stromal tumor resistant to standard tyrosine kinase inhibitors. Oncotarget 8:76712-76721 (2017). PubMed: 29100343
  • Qian LQ  et al. Downregulation of MACC1 inhibits the viability, invasion and migration and induces apoptosis in esophageal carcinoma cells through the phosphatase and tensin homolog/phosphoinositide 3-kinase/protein kinase B signaling pathway. Oncol Lett 14:4897-4905 (2017). PubMed: 29085498
  • Javadi A  et al. PTEN controls glandular morphogenesis through a juxtamembrane ß-Arrestin1/ARHGAP21 scaffolding complex. Elife 6:N/A (2017). PubMed: 28749339
  • Huang ZJ  et al. NEDD4 promotes cell growth and migration via PTEN/PI3K/AKT signaling in hepatocellular carcinoma. Oncol Lett 14:2649-2656 (2017). PubMed: 28928809
  • Shao P  et al. MicroRNA-205-5p regulates the chemotherapeutic resistance of hepatocellular carcinoma cells by targeting PTEN/JNK/ANXA3 pathway. Am J Transl Res 9:4300-4307 (2017). PubMed: 28979703
  • Hu G  et al. Single-cell RNA-seq reveals distinct injury responses in different types of DRG sensory neurons. Sci Rep 6:31851 (2016). IHC . PubMed: 27558660
  • Ma J  et al. microRNA-22 attenuates neuronal cell apoptosis in a cell model of traumatic brain injury. Am J Transl Res 8:1895-902 (2016). WB ; Rat . PubMed: 27186313
  • Chang H  et al. EGFR protein expression using a specific intracellular domain antibody and PTEN and clinical outcomes in squamous cell lung cancer patients with EGFR-tyrosine kinase inhibitor therapy. Onco Targets Ther 9:5153-62 (2016). IHC ; Human . PubMed: 27578983
  • Gusscott S  et al. IGF1R Derived PI3K/AKT Signaling Maintains Growth in a Subset of Human T-Cell Acute Lymphoblastic Leukemias. PLoS One 11:e0161158 (2016). WB . PubMed: 27532210
  • He S  et al. Upregulation of PREX2 promotes the proliferation and migration of hepatocellular carcinoma cells via PTEN-AKT signaling. Oncol Lett 11:2223-2228 (2016). Human . PubMed: 26998152
  • Yang J  et al. PREX2 promotes the proliferation, invasion and migration of pancreatic cancer cells by modulating the PI3K signaling pathway. Oncol Lett 12:1139-1143 (2016). WB ; Human . PubMed: 27446408
  • Bei Y  et al. miR-382 targeting PTEN-Akt axis promotes liver regeneration. Oncotarget 7:1584-97 (2016). WB . PubMed: 26636539
  • Fan Y  et al. Cytotoxic effects of ß-carboline alkaloids on human gastric cancer SGC-7901 cells. Int J Clin Exp Med 8:12977-82 (2015). PubMed: 26550217
  • Serra H  et al. PTEN mediates Notch-dependent stalk cell arrest in angiogenesis. Nat Commun 6:7935 (2015). PubMed: 26228240
  • Geng J  et al. Down-regulation of USP13 mediates phenotype transformation of fibroblasts in idiopathic pulmonary fibrosis. Respir Res 16:124 (2015). WB . PubMed: 26453058
  • He M  et al. KLF4 mediates the link between TGF-ß1-induced gene transcription and H3 acetylation in vascular smooth muscle cells. FASEB J 29:4059-70 (2015). PubMed: 26082460
  • Li CJ  et al. MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation. J Clin Invest 125:1509-22 (2015). WB ; Mouse . PubMed: 25751060
  • Sellerio AL  et al. Overshoot during phenotypic switching of cancer cell populations. Sci Rep 5:15464 (2015). PubMed: 26494317
  • Liao HF  et al. DNMT3L promotes quiescence in postnatal spermatogonial progenitor cells. Development 141:2402-13 (2014). PubMed: 24850856
  • Ngalame NN  et al. Aberrant microRNA expression likely controls RAS oncogene activation during malignant transformation of human prostate epithelial and stem cells by arsenic. Toxicol Sci 138:268-77 (2014). PubMed: 24431212
  • Screen M  et al. Abnormal splicing of NEDD4 in myotonic dystrophy type 2: possible link to statin adverse reactions. Am J Pathol 184:2322-32 (2014). PubMed: 24907641
  • Hammond VE  et al. Ndfip1 Is Required for the Development of Pyramidal Neuron Dendrites and Spines in the Neocortex. Cereb Cortex N/A:N/A (2013). PubMed: 23897647
  • Surviladze Z  et al. Cellular entry of human papillomavirus type 16 involves activation of the phosphatidylinositol 3-kinase/Akt/mTOR pathway and inhibition of autophagy. J Virol 87:2508-17 (2013). PubMed: 23255786
  • Kucherlapati MH  et al. Genotype directed therapy in murine mismatch repair deficient tumors. PLoS One 8:e68817 (2013). PubMed: 23935891
  • Xu Y  et al. Recruitment of normal stem cells to an oncogenic phenotype by noncontiguous carcinogen-transformed epithelia depends on the transforming carcinogen. Environ Health Perspect 121:944-50 (2013). WB ; Human . PubMed: 23687063
  • Howitt J  et al. Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia. J Cell Biol 196:29-36 (2012). PubMed: 22213801
  • Sangale Z  et al. A robust immunohistochemical assay for detecting PTEN expression in human tumors. Appl Immunohistochem Mol Morphol 19:173-83 (2011). PubMed: 20930614
  • Manna P & Jain SK Hydrogen Sulfide and L-Cysteine Increase Phosphatidylinositol 3,4,5-Trisphosphate (PIP3) and Glucose Utilization by Inhibiting Phosphatase and Tensin Homolog (PTEN) Protein and Activating Phosphoinositide 3-Kinase (PI3K)/Serine/Threonine Protein Kinase (AKT)/Protein Kinase C?/? (PKC?/?) in 3T3l1 Adipocytes. J Biol Chem 286:39848-59 (2011). WB ; Mouse . PubMed: 21953448
  • Medyouf H  et al. Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss. Blood 115:1175-84 (2010). Flow Cyt ; Human . PubMed: 20008304
  • Akesson E  et al. Prognostic significance of estrogen and progesterone receptor expression in LNG-IUS (Mirena) treatment of endometrial hyperplasia: an immunohistochemical study. Acta Obstet Gynecol Scand 89:393-8 (2010). IHC-P ; Human . PubMed: 20199355
  • Wargon V  et al. Hypermethylation of the progesterone receptor A in constitutive antiprogestin-resistant mouse mammary carcinomas. Breast Cancer Res Treat : (2010). WB ; Mouse . PubMed: 20440553
  • Vlashi E  et al. Differential Effects of the Proteasome Inhibitor NPI-0052 against Glioma Cells. Transl Oncol 3:50-5 (2010). WB ; Human . PubMed: 20165695
  • Lee DY  et al. Expression of Versican 3'-Untranslated Region Modulates Endogenous MicroRNA Functions. PLoS One 5:e13599 (2010). WB, IHC-P ; Mouse . PubMed: 21049042
  • Diegel CR  et al. Mammalian target of rapamycin-dependent acinar cell neoplasia after inactivation of apc and pten in the mouse salivary gland: implications for human acinic cell carcinoma. Cancer Res 70:9143-52 (2010). IHC-P ; Mouse . PubMed: 21062985
  • Zeiser R  et al. Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells. Blood 111:453-62 (2008). PubMed: 17967941


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