The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1000. Predicted molecular weight: 35 kDa.
FunctionTranscriptional activator. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays an important role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells (By similarity). Plays an important role in cerebellar development.
Tissue specificityPancreas-specific (at protein level). Loss of expression is seen in ductal type pancreas cancers.
Involvement in diseaseDefects in PTF1A are the cause of diabetes mellitus and cerebellar hypoplasia/agenesis (DMCH) [MIM:609069].
Cellular localizationNucleus. Cytoplasm. In chronic pancreatitis associated with pancreas cancer preferentially accumulates in the cytoplasm of acinar/ductular complexes. In the cytoplasm loses its ability to form the PTF1 complex.
FormPTF1A is a pancreas specific transcription factor. Mammalian studies have implicated important roles for the basic helix-loop-helix transcription factor PTF1A-p48 in the development of both exocrine and endocrine pancreas.
bHLH transcription factor p48 antibody
Class A basic helix-loop-helix protein 29 antibody
Class II bHLH protein PTF1A antibody
Exocrine pancreas specific transcription factor p48 antibody
p48 DNA binding subunit of transcription factor PTF1 antibody
p48 DNA-binding subunit of transcription factor PTF1 antibody
Pancreas specific transcription factor 1a antibody