Overview

  • Product nameAnti-PTHLH antibody
  • Description
    Rabbit polyclonal to PTHLH
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Cow, Dog, Pig
  • Immunogen

    Recombinant fragment containing a sequence corresponding to a region within amino acids 1-127 of Human PTHLH.(Uniprot: P12272)

  • Positive control
    • A549 cell lysate, HepG2 cell lysate and HTC116 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab125700 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 20 kDa.

Target

  • FunctionNeuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.
    Osteostatin is a potent inhibitor of osteoclastic bone resorption.
  • Tissue specificityUbiquitous. Also expressed in the mammary gland.
  • Involvement in diseaseDefects in PTHLH are the cause of brachydactyly type E2 (BDE2) [MIM:613382]. BDE2 is a form of brachydactyly. Brachydactyly defines a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. Brachydactyly type E is characterized by shortening of the fingers mainly in the metacarpals and metatarsals. Wide variability in the number of digits affected occurs from person to person, even in the same family. Some individuals are moderately short of stature. In brachydactyly type E2 variable combinations of metacarpals are involved, with shortening also of the first and third distal and the second and fifth middle phalanges.
  • Sequence similaritiesBelongs to the parathyroid hormone family.
  • Post-translational
    modifications
    There are 3 principal secretory forms, called PTHrP[1-36], PTHrP[38-94], and osteostatin (PTHrP[107-139]) arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.
  • Cellular localizationCytoplasm. Nucleus. Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Osteostatin antibody
    • Parathyroid hormone-like hormone antibody
    • Parathyroid hormone-like protein antibody
    • PLP antibody
    • PTH related protein antibody
    • PTH-rP antibody
    • PTHLH antibody
    • PTHR antibody
    • PTHR_HUMAN antibody
    • PTHrP antibody
    • PTHrP[107-139] antibody
    see all

Anti-PTHLH antibody images

  • All lanes : Anti-PTHLH antibody (ab125700) at 1/1000 dilution

    Lane 1 : HepG2 lysate
    Lane 2 : HCT116 lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 20 kDa

References for Anti-PTHLH antibody (ab125700)

ab125700 has not yet been referenced specifically in any publications.

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