Overview

  • Product name
  • Description
    Rabbit polyclonal to PTHLH
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Sheep
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Cow, Cat, Dog, Human, Pig, Deer
  • Immunogen

    Synthetic peptide:

    NSKPSPNTKNHPVRF

    conjugated to KLH, corresponding to amino acids 45-59 of PTHLH

  • Positive control
    • Ovine kidney

Properties

Applications

Our Abpromise guarantee covers the use of ab53414 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notes
    ELISA: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution.

    Gives Strong Bands (v faint in pre-immune) at 30, 33, 36 kD. There are at least 3
    isoforms of PTHRP precursor 21-25 kD by sequence alone. Not tested by blocking.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.
      Osteostatin is a potent inhibitor of osteoclastic bone resorption.
    • Tissue specificity
      Ubiquitous. Also expressed in the mammary gland.
    • Involvement in disease
      Brachydactyly E2
    • Sequence similarities
      Belongs to the parathyroid hormone family.
    • Post-translational
      modifications
      There are 3 principal secretory forms, called PTHrP[1-36], PTHrP[38-94], and osteostatin (PTHrP[107-139]) arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.
    • Cellular localization
      Cytoplasm. Nucleus. Secreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • HHM antibody
      • MGC14611 antibody
      • Osteostatin antibody
      • Parathyroid hormon like hormone isoform 2 preproprotein antibody
      • Parathyroid hormone like hormone antibody
      • Parathyroid hormone like hormone isoform 1 preproprotein antibody
      • Parathyroid hormone like protein antibody
      • Parathyroid hormone like related protein antibody
      • Parathyroid hormone related protein antibody
      • Parathyroid hormone-like protein antibody
      • Parathyroid like protein antibody
      • PLP antibody
      • PTH related protein antibody
      • PTH-rP antibody
      • PTHLH antibody
      • PTHR antibody
      • PTHR_HUMAN antibody
      • PTHrP antibody
      • PTHrP[107-139] antibody
      see all

    References for Anti-PTHLH antibody (ab53414)

    ab53414 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab53414.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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