Overview

  • Product name
  • Description
    Rabbit polyclonal to PTP epsilon
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide from the C-terminal region of human PTP epsilon, KLH conjugated.

  • Positive control
    • human Placental lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab71553 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 81 kDa (predicted molecular weight: 81 kDa).

Target

  • Function
    Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function.
    Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake.
    Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+).
  • Tissue specificity
    Expressed in giant cell tumor (osteoclastoma rich in multinucleated osteoclastic cells).
  • Sequence similarities
    Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
    Contains 2 tyrosine-protein phosphatase domains.
  • Domain
    The tyrosine-protein phosphatase 2 domain (D2) mediates dimerization. The extreme N- and C- termini of the D2 domain act to inhibit dimerization and removal of these sequences increases dimerization and inhibits enzyme activity.
  • Post-translational
    modifications
    A catalytically active cytoplasmic form (p65) is produced by proteolytic cleavage of either isoform 1, isoform 2 or isoform 3.
    Isoform 1 and isoform 2 are phosphorylated on tyrosine residues by tyrosine kinase Neu.
    Isoform 1 is glycosylated.
  • Cellular localization
    Cytoplasm; Cell membrane and Cytoplasm. Predominantly cytoplasmic. A small fraction is also associated with nucleus and membrane. Insulin induces translocation to the membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • DKFZp313F1310 antibody
    • FLJ57799 antibody
    • FLJ58245 antibody
    • HPTPE antibody
    • Protein tyrosine phosphatase epsilon antibody
    • Protein tyrosine phosphatase receptor type E antibody
    • Protein tyrosine phosphatase receptor type epsilon antibody
    • Protein tyrosine phosphatase receptor type epsilon polypeptide antibody
    • Protein-tyrosine phosphatase epsilon antibody
    • PTPE antibody
    • Ptpre antibody
    • PTPRE_HUMAN antibody
    • R PTP Epsilon antibody
    • R-PTP-epsilon antibody
    • Receptor-type tyrosine-protein phosphatase epsilon antibody
    see all

Images

  • Anti-PTP epsilon antibody (ab71553) at 1/100 dilution + human placenta lysate at 12.5 µg

    Predicted band size : 81 kDa
    Observed band size : 81 kDa
    Additional bands at : 100 kDa,50 kDa,60 kDa. We are unsure as to the identity of these extra bands.

References

ab71553 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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