• Product nameAnti-PTP epsilon antibody
    See all PTP epsilon primary antibodies
  • Description
    Rabbit polyclonal to PTP epsilon
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Drosophila melanogaster, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within internal amino acids 468-517 (VILSMKRGQE YTDYINASFI DGYRQKDYFI ATQGPLAHTV EDFWRMIWEW) of Human PTP epsilon (NP_006495)

  • Positive control
    • 293T cell lysate.



Our Abpromise guarantee covers the use of ab84681 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 81 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • FunctionIsoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function.
    Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake.
    Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+).
  • Tissue specificityExpressed in giant cell tumor (osteoclastoma rich in multinucleated osteoclastic cells).
  • Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
    Contains 2 tyrosine-protein phosphatase domains.
  • DomainThe tyrosine-protein phosphatase 2 domain (D2) mediates dimerization. The extreme N- and C- termini of the D2 domain act to inhibit dimerization and removal of these sequences increases dimerization and inhibits enzyme activity.
  • Post-translational
    A catalytically active cytoplasmic form (p65) is produced by proteolytic cleavage of either isoform 1, isoform 2 or isoform 3.
    Isoform 1 and isoform 2 are phosphorylated on tyrosine residues by tyrosine kinase Neu.
    Isoform 1 is glycosylated.
  • Cellular localizationCytoplasm; Cell membrane and Cytoplasm. Predominantly cytoplasmic. A small fraction is also associated with nucleus and membrane. Insulin induces translocation to the membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • DKFZp313F1310 antibody
    • FLJ57799 antibody
    • FLJ58245 antibody
    • HPTPE antibody
    • Protein tyrosine phosphatase epsilon antibody
    • Protein tyrosine phosphatase receptor type E antibody
    • Protein tyrosine phosphatase receptor type epsilon antibody
    • Protein tyrosine phosphatase receptor type epsilon polypeptide antibody
    • Protein-tyrosine phosphatase epsilon antibody
    • PTPE antibody
    • Ptpre antibody
    • PTPRE_HUMAN antibody
    • R PTP Epsilon antibody
    • R-PTP-epsilon antibody
    • Receptor-type tyrosine-protein phosphatase epsilon antibody
    see all

Anti-PTP epsilon antibody images

  • Anti-PTP epsilon antibody (ab84681) at 1 µg/ml (in 5% skim milk / PBS buffer) + 293T cell lysate at 10 µg

    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 81 kDa
    Observed band size : 88 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 36 kDa,>90 kDa. We are unsure as to the identity of these extra bands.

References for Anti-PTP epsilon antibody (ab84681)

ab84681 has not yet been referenced specifically in any publications.

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