Overview

  • Product nameAnti-PTP1B antibody [107AT690]
    See all PTP1B primary antibodies
  • Description
    Mouse monoclonal [107AT690] to PTP1B
  • Tested applicationsSuitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Recombinant full length protein (Human)

  • Positive control
    • Mouse lung tissue lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab38674 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 50 kDa (predicted molecular weight: 50 kDa).

Target

  • FunctionMay play an important role in CKII- and p60c-src-induced signal transduction cascades.
  • Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.
    Contains 1 tyrosine-protein phosphatase domain.
  • Post-translational
    modifications
    Oxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the following residue to form a 4-amino-3-isothiazolidinone serine cross-link, triggering a conformational change that inhibits substrate binding and activity. The active site can be restored by reduction.
  • Cellular localizationEndoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • PTP1B antibody
    • Non receptor tyrosine phosphatase 1 antibody
    • Protein phosphotyrosylphosphatase 1B antibody
    • Protein tyrosine phosphatase 1B antibody
    • Protein tyrosine phosphatase non receptor type 1 antibody
    • Protein tyrosine phosphatase placental antibody
    • Protein-tyrosine phosphatase 1B antibody
    • PTN1_HUMAN antibody
    • PTP 1B antibody
    • PTP-1B antibody
    • PTPN 1 antibody
    • PTPN1 antibody
    • Tyrosine protein phosphatase non receptor type 1 antibody
    • Tyrosine-protein phosphatase non-receptor type 1 antibody
    see all

Anti-PTP1B antibody [107AT690] images

  • All lanes : Anti-PTP1B antibody [107AT690] (ab38674) at 1/100 dilution

    Lane 1 : Mouse lung tissue lysate
    Lane 2 : Recombinant protein PTP1b (1-321)


    Predicted band size : 50 kDa
    Observed band size : 35,50 kDa (why is the actual band size different from the predicted?)

References for Anti-PTP1B antibody [107AT690] (ab38674)

ab38674 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"