The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Hypothetical protein DKFZp779M0721
Phosphatase of regenerating liver 1
Protein tyrosine phosphatase PTPCAAX1
Protein tyrosine phosphatase type IVA 1
Protein tyrosine phosphatase type IVA member 1
Protein-tyrosine phosphatase 4a1
Protein-tyrosine phosphatase of regenerating liver 1
Protein-tyrosine phosphatase, type 4A, 1
FunctionProtein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.
Tissue specificityExpressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines.
Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Contains 1 tyrosine-protein phosphatase domain.
Developmental stageExpressed in fetal liver.
Post-translational modificationsFarnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus.
Cellular localizationCell membrane. Early endosome. Endoplasmic reticulum. Cytoplasm. Cytoplasm > cytoskeleton > spindle. And mitotic spindle.