Overview

  • Product name
    Anti-PTP4A3 antibody [111AT714]
    See all PTP4A3 primary antibodies
  • Description
    Mouse monoclonal [111AT714] to PTP4A3
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Recombinant full length protein corresponding to Mouse PTP4A3.

  • Positive control
    • WB: 293 cells transfected with PTP4A3.

Properties

Applications

Our Abpromise guarantee covers the use of ab38673 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 20 kDa.
ICC/IF Use at an assay dependent concentration. PubMed: 19586538

Target

  • Function
    Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
  • Tissue specificity
    Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis.
  • Sequence similarities
    Belongs to the protein-tyrosine phosphatase family.
    Contains 1 tyrosine-protein phosphatase domain.
  • Post-translational
    modifications
    Farnesylated. Farnesylation is required for membrane targeting.
  • Cellular localization
    Cell membrane. Early endosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • Potentially prenylated protein tyrosine phosphatase antibody
    • PRL 3 antibody
    • PRL R antibody
    • PRL-3 antibody
    • PRL-R antibody
    • PRL3 antibody
    • PRLR antibody
    • Protein tyrosine phosphatase 4a3 antibody
    • Protein tyrosine phosphatase type IVA 3 antibody
    • Protein-tyrosine phosphatase 4a3 antibody
    • Protein-tyrosine phosphatase of regenerating liver 3 antibody
    • PTP 4A3 antibody
    • PTP4A3 antibody
    • TP4A3_HUMAN antibody
    see all

Anti-PTP4A3 antibody [111AT714] images

  • Anti-PTP4A3 antibody [111AT714] (ab38673) at 1/100 dilution + 293 cells transfected with PTP4A3 at 35 µg

    Predicted band size : 20 kDa
    Observed band size : 20 kDa

References for Anti-PTP4A3 antibody [111AT714] (ab38673)

This product has been referenced in:
  • Molleví DG  et al. PRL-3 overexpression in epithelial cells is induced by surrounding stromal fibroblasts. Mol Cancer 8:46 (2009). ICC/IF ; Human . Read more (PubMed: 19586538) »

See 1 Publication for this product

Product Wall

Application
Western blot
Sample
Human Recombinant protein (COS7 extract expressing both HA-tagged and no-tag)
Loading amount
20 µg
Specification
COS7 extract expressing both HA-tagged and no-tag
Gel Running Conditions
Reduced Denaturing (15 % SDS-PAG)
Blocking step
Blocking One as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 100%
Username

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Submitted Apr 17 2009

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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