Overview

  • Product nameAnti-PTP4A3 antibody
    See all PTP4A3 primary antibodies
  • Description
    Rabbit polyclonal to PTP4A3
  • Specificityab50276 recognizes human PRL-3 and does not cross-react with human PRL-1 and PRL-2.
  • Tested applicationsSuitable for: WB, IHC-P, IP, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide:

    FKDPHTHKTR

    conjugated to KLH by an N-terminal Cysteine residue linker, corresponding to amino acids 160-169 of Human PTP4A3

  • Positive control
    • Whole extract of human HepG2 cells, protease digested formalin-fixed, paraffin-embedded human heart sections and recombinant human PRL-3.

Properties

Applications

Our Abpromise guarantee covers the use of ab50276 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 19 kDa. Staining can be inhibited by the immunizing peptide.
IHC-P 1/250 - 1/500.
IP Use a concentration of 0.5 - 1 µg/ml.
ICC/IF Use at an assay dependent concentration. PubMed: 22345654

Target

  • FunctionProtein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
  • Tissue specificityMainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis.
  • Sequence similaritiesBelongs to the protein-tyrosine phosphatase family.
    Contains 1 tyrosine-protein phosphatase domain.
  • Post-translational
    modifications
    Farnesylated. Farnesylation is required for membrane targeting.
  • Cellular localizationCell membrane. Early endosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • Potentially prenylated protein tyrosine phosphatase antibody
    • PRL 3 antibody
    • PRL R antibody
    • PRL-3 antibody
    • PRL-R antibody
    • PRL3 antibody
    • PRLR antibody
    • Protein tyrosine phosphatase 4a3 antibody
    • Protein tyrosine phosphatase type IVA 3 antibody
    • Protein-tyrosine phosphatase 4a3 antibody
    • Protein-tyrosine phosphatase of regenerating liver 3 antibody
    • PTP 4A3 antibody
    • PTP4A3 antibody
    • TP4A3_HUMAN antibody
    see all

References for Anti-PTP4A3 antibody (ab50276)

This product has been referenced in:
  • Xing C  et al. Ubiquitin-Specific Protease 4-Mediated Deubiquitination and Stabilization of PRL-3 Is Required for Potentiating Colorectal Oncogenesis. Cancer Res 76:83-95 (2016). Read more (PubMed: 26669864) »
  • Mayinuer A  et al. Upregulation of protein tyrosine phosphatase type IVA member 3 (PTP4A3/PRL-3) is associated with tumor differentiation and a poor prognosis in human hepatocellular carcinoma. Ann Surg Oncol 20:305-17 (2013). IHC-P ; Human . Read more (PubMed: 23064776) »

See all 5 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"