Overview

  • Product nameAnti-PTPN13 antibody [AC21]
    See all PTPN13 primary antibodies
  • Description
    Mouse monoclonal [AC21] to PTPN13
  • SpecificityHuman PTPN13 protein.
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Prokaryotic recombinant fusion protein corresponding to N terminal amino acids 239-342 of Human PTPN13 (Fas-associated phosphatase 1).

  • Positive control
    • Tonsil and normal human thyroid.
  • General notesStaining pattern is mainly cytoplasmic with occasional nuclear staining observed.

Properties

Applications

Our Abpromise guarantee covers the use of ab49446 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/40 - 1/80. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. Incubate with primary antibody for 60 minutes at 25°C.

Target

  • RelevancePTPN13 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as I-kappa-B-alpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway.
  • Cellular localizationCytoplasmic
  • Database links
  • Alternative names
    • APO1/CD95 (Fas) associated phosphatase antibody
    • DKFZp686J1497 antibody
    • FAP 1 antibody
    • FAP1 antibody
    • Fas associated phosphatase 1 antibody
    • Fas associated protein tyrosine phosphatase 1 antibody
    • HGNC:9646 antibody
    • hPTPE1 antibody
    • Phosphatase rip antibody
    • PNP 1 antibody
    • PNP1 antibody
    • Protein tyrosine phosphatase 1 Fas associated antibody
    • protein tyrosine phosphatase 1E antibody
    • Protein tyrosine phosphatase non receptor type 13 antibody
    • Protein tyrosine phosphatase nonreceptor type 13 antibody
    • Protein tyrosine phosphatase PTPL1 antibody
    • protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) antibody
    • PTP BAS antibody
    • PTP BL antibody
    • PTP E1 antibody
    • PTP1E antibody
    • PTPL 1 antibody
    • PTPL1 antibody
    • PTPLE antibody
    • PTPN 13 antibody
    • PTPN13 antibody
    • Tyrosine protein phosphatase non receptor type 13 antibody
    see all

Anti-PTPN13 antibody [AC21] images

  • Immunohistochemical staining (Paraffin section) for PTPN13 (Fas-associated phosphatase 1) using ab49446 with normal Human thyroid as positive control. Note intense cytoplasmic staining of thyroid epithelial cells.

References for Anti-PTPN13 antibody [AC21] (ab49446)

This product has been referenced in:
  • Glondu-Lassis M  et al. PTPL1/PTPN13 regulates breast cancer cell aggressiveness through direct inactivation of Src kinase. Cancer Res 70:5116-26 (2010). IHC-P ; Human . Read more (PubMed: 20501847) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"