Overview

  • Product name
  • Description
    Goat polyclonal to PTPN22
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    CPPNKPAESVQSNNS

    , corresponding to C terminal amino acids 766-780 of Human PTPN22 (NP_057051.3)

  • Positive control
    • Human adrenal, thyroid and small intestine tissues.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 0.5% BSA, 98% Tris buffered saline
  • Concentration information loading...
  • Purity
    Protein G purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab118430 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3.75 - 7.5 µg/ml.

Target

  • Function
    Seems to act on Cbl. May play a role in regulating the function of Cbl and its associated protein kinases. Acts as negative regulator of T cell receptor (TCR) signaling. Dephosphorylates and inactivates the SRC family kinases.
  • Tissue specificity
    Predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells.
  • Sequence similarities
    Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.
    Contains 1 tyrosine-protein phosphatase domain.
  • Post-translational
    modifications
    Phosphorylation on Ser-35 by PKC/PRKCD abrogates its ability to dephosphorylate and inactivate the SRC family kinases.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • Hematopoietic cell protein tyrosine phosphatase 70Z PEP antibody
    • Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP antibody
    • Lymphoid phosphatase antibody
    • Lymphoid specific protein tyrosine phosphatase antibody
    • lymphoid-specific, inducible human protein tyrosine phosphatase antibody
    • Lyp 1 antibody
    • Lyp 2 antibody
    • LyP antibody
    • Lyp1 antibody
    • Lyp2 antibody
    • LyPTP antibody
    • OTTHUMP00000013720 antibody
    • OTTHUMP00000013721 antibody
    • OTTHUMP00000233450 antibody
    • OTTHUMP00000233451 antibody
    • PEP antibody
    • PEST-domain phosphatase antibody
    • Protein tyrosine phosphatase non receptor type 22 (lymphoid) antibody
    • Protein tyrosine phosphatase non receptor type 22 antibody
    • Protein tyrosine phosphatase non receptor type 8 antibody
    • Protein tyrosine phosphatase non receptor type 8, formerly antibody
    • PTN22_HUMAN antibody
    • PTPN 22 antibody
    • PTPN 8 antibody
    • Ptpn22 antibody
    • PTPN8 antibody
    • PTPN8, formerly antibody
    • Tyrosine-protein phosphatase non-receptor type 22 antibody
    see all

Images

  • ab118430 at 7.5ug/ml staining PTPN22 in Formalin-fixed, Paraffin-embedded Human adrenal tissue by Immunohistochemistry.
  • ab118430 at 7.5ug/ml staining PTPN22 in Formalin-fixed, Paraffin-embedded Human thyroid tissue by Immunohistochemistry.
  • ab118430 at 7.5ug/ml staining PTPN22 in Formalin-fixed, Paraffin-embedded Human small intestine tissue by Immunohistochemistry.

References

ab118430 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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