Overview

  • Product name
  • Description
    Mouse polyclonal to PTPN22
  • Host species
    Mouse
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein, corresponding to amino acids 1-752 of Human PTPN22 Isoform 3 (AAH71670.1).

  • Positive control
    • PTPN22 transfected 293T cell lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer
    pH: 7.20
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab169040 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 85 kDa.

Target

  • Function
    Seems to act on Cbl. May play a role in regulating the function of Cbl and its associated protein kinases. Acts as negative regulator of T cell receptor (TCR) signaling. Dephosphorylates and inactivates the SRC family kinases.
  • Tissue specificity
    Predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells.
  • Sequence similarities
    Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.
    Contains 1 tyrosine-protein phosphatase domain.
  • Post-translational
    modifications
    Phosphorylation on Ser-35 by PKC/PRKCD abrogates its ability to dephosphorylate and inactivate the SRC family kinases.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • Hematopoietic cell protein tyrosine phosphatase 70Z PEP antibody
    • Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP antibody
    • Lymphoid phosphatase antibody
    • Lymphoid specific protein tyrosine phosphatase antibody
    • lymphoid-specific, inducible human protein tyrosine phosphatase antibody
    • Lyp 1 antibody
    • Lyp 2 antibody
    • LyP antibody
    • Lyp1 antibody
    • Lyp2 antibody
    • LyPTP antibody
    • OTTHUMP00000013720 antibody
    • OTTHUMP00000013721 antibody
    • OTTHUMP00000233450 antibody
    • OTTHUMP00000233451 antibody
    • PEP antibody
    • PEST-domain phosphatase antibody
    • Protein tyrosine phosphatase non receptor type 22 (lymphoid) antibody
    • Protein tyrosine phosphatase non receptor type 22 antibody
    • Protein tyrosine phosphatase non receptor type 8 antibody
    • Protein tyrosine phosphatase non receptor type 8, formerly antibody
    • PTN22_HUMAN antibody
    • PTPN 22 antibody
    • PTPN 8 antibody
    • Ptpn22 antibody
    • PTPN8 antibody
    • PTPN8, formerly antibody
    • Tyrosine-protein phosphatase non-receptor type 22 antibody
    see all

Images

  • All lanes : Anti-PTPN22 antibody (ab169040) at 1 µg/ml

    Lane 1 : PTPN22 transfected 293T cell lysate
    Lane 2 : non transfected 293T cell lysate

    Lysates/proteins at 15 µl per lane.

    Secondary
    All lanes : Goat anti-mouse HRP conjugated antibody at 1/2500 dilution

    Developed using the ECL technique.

    Predicted band size: 85 kDa

References

ab169040 has not yet been referenced specifically in any publications.

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There are currently no Customer reviews or Questions for ab169040.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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