Overview

  • Product nameAnti-PTPRB antibody [122.2]
  • Description
    Mouse monoclonal [122.2] to PTPRB
  • SpecificityThis antibody is specific for Receptor Tyrosine Phosphatase Beta (phosphacan).
  • Tested applicationsSuitable for: WB, ICC/IF, ICC, IPmore details
  • Species reactivity
    Reacts with: Rat
  • Immunogen

    Embryonic rat brain proteoglycans.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage bufferPreservative: None
    Constituents: PBS
  • Concentration information loading...
  • Purification notesConcentrated antibody. This antibody was grown in protein free medium, then concentrated snd dialysed against PBS.
  • ClonalityMonoclonal
  • Clone number122.2
  • IsotypeIgM
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab31654 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/2500. Predicted molecular weight: 224 kDa.
ICC/IF Use at an assay dependent dilution.
ICC Use at an assay dependent dilution.
IP Use at an assay dependent dilution.

Target

  • FunctionPlays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin.
  • Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
    Contains 17 fibronectin type-III domains.
    Contains 1 tyrosine-protein phosphatase domain.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Alternative names
    • HPTP BETA antibody
    • HPTPB antibody
    • Phosphacan receptor type B antibody
    • Protein tyrosine phosphatase receptor type B antibody
    • Protein-tyrosine phosphatase beta antibody
    • PTPB antibody
    • Ptprb antibody
    • PTPRB_HUMAN antibody
    • R PTP BETA antibody
    • R-PTP-beta antibody
    • Receptor-type tyrosine-protein phosphatase beta antibody
    • RPTPB antibody
    • Vascular endothelial protein tyrosine phosphatase antibody
    • VE-PTP antibody
    see all

References for Anti-PTPRB antibody [122.2] (ab31654)

ab31654 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"