Overview

  • Product nameAnti-PTRF antibody
    See all PTRF primary antibodies
  • Description
    Mouse monoclonal to PTRF
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: KKAFSKEKME KTKVRTRENL EKTRLKTKEN LEKTRHTLEK RMNKLGTRLV PAERREKLKT SRDKLRKSFT PDHVVYARSK TAVYKVPPF, corresponding to amino acids 233-322 of Human PTRF

Properties

Applications

Our Abpromise guarantee covers the use of ab58019 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notes
    IHC-P: Use at a concentration of 3 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionPlays an important role in caveolae formation and organization. Required for the sequestration of mobile caveolin into immobile caveolae. Termination of transcription by RNA polymerase I involves pausing of transcription by TTF1, and the dissociation of the transcription complex, releasing pre-rRNA and RNA polymerase I from the template. PTRF is required for dissociation of the ternary transcription complex.
    • Involvement in diseaseCongenital generalized lipodystrophy 4
    • Sequence similaritiesBelongs to the PTRF/SDPR family.
    • Post-translational
      modifications
      Phosphorylated. Present in active and inactive forms. Changes in phosphorylation pattern may alter activity.
      Five truncated forms are found in the caveolae. These are thought to be the result of proteolysis and may be phosphorylation-dependent.
    • Cellular localizationMembrane > caveola. Cell membrane. Microsome. Endoplasmic reticulum. Cytoplasm > cytosol. Mitochondrion. Nucleus. Found at the surface of the caveolae. Also found in the plasma membrane, microsomal and cytosolic fractions and at a low level in the mitochondrial and nuclear fractions. Translocates to the cytoplasm from the caveolae upon insulin stimulation. CAV1 is necessary to recruit it to the cell membrane (By similarity). Co-localizes with CAV1 in lipid rafts in adipocytes.
    • Information by UniProt
    • Database links
    • Alternative names
      • 2310075E07Rik antibody
      • AW546441 antibody
      • Cavin 1 antibody
      • Cavin antibody
      • Cavin-1 antibody
      • CAVIN1 antibody
      • CGL4 antibody
      • FKSG13 antibody
      • FLJ90031 antibody
      • MGC118550 antibody
      • OTTMUSP00000002049 antibody
      • Polymerase I and transcript release factor antibody
      • Ptrf antibody
      • PTRF_HUMAN antibody
      • RNA polymerase I and transcript release factor antibody
      • RP23-279L23.6 antibody
      • TTF I interacting peptide 12 antibody
      see all

    Anti-PTRF antibody images

    • PTRF antibody (ab58019) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human pancreas.

    References for Anti-PTRF antibody (ab58019)

    ab58019 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"