Overview

  • Product nameAnti-PTS antibody
    See all PTS primary antibodies
  • Description
    Rabbit polyclonal to PTS
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1 - 111 of Human PTS (NP_000308).

  • Positive control
    • 293T, H1299 and HeLa cells

Properties

Applications

Our Abpromise guarantee covers the use of ab96104 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 16 kDa.

Target

  • FunctionInvolved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
  • PathwayCofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3.
  • Involvement in diseaseDefects in PTS are the cause of BH4-deficient hyperphenylalaninemia type A (HPABH4A) [MIM:261640]; also called 6-pyruvoyl-tetrahydropterin synthase deficiency (PTS deficiency) or hyperphenylalaninemia tetrahydrobiopterin-deficient due to PTS deficiency. HPABH4A is an autosomal recessive disorder characterized by depletion of the neurotransmitters dopamine and serotonin, and clinically by severe neurological symptoms unresponsive to the classic phenylalanine-low diet.
  • Sequence similaritiesBelongs to the PTPS family.
  • Post-translational
    modifications
    Phosphorylation of Ser-19 is required for maximal enzyme activity.
  • Information by UniProt
  • Database links
  • Alternative names
    • 6 pyruvoyl tetrahydrobiopterin synthase antibody
    • 6 pyruvoyl tetrahydropterin synthase antibody
    • 6 pyruvoyltetrahydropterin synthase antibody
    • 6-pyruvoyl tetrahydrobiopterin synthase antibody
    • EC 4.2.3.12 antibody
    • FLJ97081 antibody
    • OTTHUMP00000235385 antibody
    • PTP synthase antibody
    • PTPS antibody
    • PTPS_HUMAN antibody
    • PTS antibody
    see all

Anti-PTS antibody images

  • Anti-PTS antibody (ab96104) at 1/1000 dilution + H1299 whole cell lysate at 30 µg

    Predicted band size : 16 kDa

References for Anti-PTS antibody (ab96104)

ab96104 has not yet been referenced specifically in any publications.

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