Overview

  • Product nameAnti-PTS antibody [AT2B2]
    See all PTS primary antibodies
  • Description
    Mouse monoclonal [AT2B2] to PTS
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-145 of Human PTS purified from E. coli (NP_000308).

  • Positive control
    • Mouse Kidney lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab106636 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/250 - 1/1000. Predicted molecular weight: 16 kDa.
ELISA Use at an assay dependent dilution.

Target

  • FunctionInvolved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
  • PathwayCofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3.
  • Involvement in diseaseDefects in PTS are the cause of BH4-deficient hyperphenylalaninemia type A (HPABH4A) [MIM:261640]; also called 6-pyruvoyl-tetrahydropterin synthase deficiency (PTS deficiency) or hyperphenylalaninemia tetrahydrobiopterin-deficient due to PTS deficiency. HPABH4A is an autosomal recessive disorder characterized by depletion of the neurotransmitters dopamine and serotonin, and clinically by severe neurological symptoms unresponsive to the classic phenylalanine-low diet.
  • Sequence similaritiesBelongs to the PTPS family.
  • Post-translational
    modifications
    Phosphorylation of Ser-19 is required for maximal enzyme activity.
  • Information by UniProt
  • Database links
  • Alternative names
    • 6 pyruvoyl tetrahydrobiopterin synthase antibody
    • 6 pyruvoyl tetrahydropterin synthase antibody
    • 6 pyruvoyltetrahydropterin synthase antibody
    • 6-pyruvoyl tetrahydrobiopterin synthase antibody
    • EC 4.2.3.12 antibody
    • FLJ97081 antibody
    • OTTHUMP00000235385 antibody
    • PTP synthase antibody
    • PTPS antibody
    • PTPS_HUMAN antibody
    • PTS antibody
    see all

Anti-PTS antibody [AT2B2] images

  • All lanes : Anti-PTS antibody [AT2B2] (ab106636) at 1/500 dilution

    Lane 1 : Mouse kidney lysate at 40 µg
    Lane 2 : Recombinant protein at 1 µg
    Lane 3 : Recombinant protein at 0.5 µg

    Secondary
    goat anti-mouse secondary antibody conjugated to HRP
    Developed using the ECL technique

    Predicted band size : 16 kDa

References for Anti-PTS antibody [AT2B2] (ab106636)

ab106636 has not yet been referenced specifically in any publications.

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