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ab9643 has been referenced in 63 publications.

  • Singh A  et al. Podophyllotoxin and Rutin Modulates Ionizing Radiation-Induced Oxidative Stress and Apoptotic Cell Death in Mice Bone Marrow and Spleen. Front Immunol 8:183 (2017). PubMed: 28289414
  • Huang J  et al. Inhibition of SKP2 Sensitizes Bromocriptine-Induced Apoptosis in Human Prolactinoma Cells. Cancer Res Treat 49:358-373 (2017). WB ; Human . PubMed: 27488872
  • Bauer MR  et al. 2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells. Proc Natl Acad Sci U S A 113:E5271-80 (2016). WB . PubMed: 27551077
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  • Tu S  et al. Effect of taurine on the proliferation and apoptosis of human hepatocellular carcinoma HepG2 cells. Exp Ther Med 10:193-200 (2015). PubMed: 26170934
  • Zhao JJ  et al. Targeting the miR-221-222/PUMA/BAK/BAX Pathway Abrogates Dexamethasone Resistance in Multiple Myeloma. Cancer Res 75:4384-4397 (2015). PubMed: 26249174
  • Bhardwaj V  et al. Helicobacter pylori bacteria alter the p53 stress response via ERK-HDM2 pathway. Oncotarget 6:1531-43 (2015). PubMed: 25605238
  • Sigurðsson HH  et al. Constitutively active ErbB2 regulates cisplatin-induced cell death in breast cancer cells via pro- and antiapoptotic mechanisms. Mol Cancer Res 13:63-77 (2015). PubMed: 25143433
  • Liu ZQ  et al. Expression of PUMA in Follicular Granulosa Cells Regulated by FoxO1 Activation During Oxidative Stress. Reprod Sci 22:696-705 (2015). IHC . PubMed: 25425107
  • Singh SP  et al. HIF-1a Plays a Critical Role in the Gestational Sidestream Smoke-Induced Bronchopulmonary Dysplasia in Mice. PLoS One 10:e0137757 (2015). WB ; Mouse . PubMed: 26361040
  • Carter BZ  et al. Synergistic effects of p53 activation via MDM2 inhibition in combination with inhibition of Bcl-2 or Bcr-Abl in CD34+ proliferating and quiescent chronic myeloid leukemia blast crisis cells. Oncotarget 6:30487-99 (2015). WB . PubMed: 26431162
  • Chen L  et al. Pre-clinical evaluation of the MDM2-p53 antagonist RG7388 alone and in combination with chemotherapy in neuroblastoma. Oncotarget 6:10207-21 (2015). WB . PubMed: 25844600
  • Goudarzi KM  et al. mTOR inhibitors blunt the p53 response to nucleolar stress by regulating RPL11 and MDM2 levels. Cancer Biol Ther 15:1499-514 (2014). Human . PubMed: 25482947
  • Holmberg Olausson K  et al. Loss of nucleolar histone chaperone NPM1 triggers rearrangement of heterochromatin and synergizes with a deficiency in DNA methyltransferase DNMT3A to drive ribosomal DNA transcription. J Biol Chem 289:34601-19 (2014). PubMed: 25349213
  • Sharp AN  et al. Preeclampsia is associated with alterations in the p53-pathway in villous trophoblast. PLoS One 9:e87621 (2014). WB ; Human . PubMed: 24498154
  • He XX  et al. Bioinformatics analysis identifies miR-221 as a core regulator in hepatocellular carcinoma and its silencing suppresses tumor properties. Oncol Rep 32:1200-10 (2014). PubMed: 24993451
  • Gang BP  et al. Targeting of two aspects of metabolism in breast cancer treatment. Cancer Biol Ther 15:1533-41 (2014). WB . PubMed: 25482950
  • Chen CY  et al. Gallic Acid Induces a Reactive Oxygen Species-Provoked c-Jun NH2-Terminal Kinase-Dependent Apoptosis in Lung Fibroblasts. Evid Based Complement Alternat Med 2013:613950 (2013). PubMed: 23533505
  • Kofod-Olsen E  et al. Inhibition of p53-dependent, but not p53-independent, cell death by U19 protein from human herpesvirus 6B. PLoS One 8:e59223 (2013). WB ; Human . PubMed: 23555634
  • Liu W  et al. Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis. J Clin Invest 123:3983-96 (2013). WB . PubMed: 23945234
  • Aliwaini S  et al. A novel binuclear palladacycle complex inhibits melanoma growth in vitro and in vivo through apoptosis and autophagy. Biochem Pharmacol 86:1650-63 (2013). Human . PubMed: 24099796
  • Caceres G  et al. TP53 suppression promotes erythropoiesis in del(5q) MDS, suggesting a targeted therapeutic strategy in lenalidomide-resistant patients. Proc Natl Acad Sci U S A 110:16127-32 (2013). PubMed: 24043769
  • Daugherity EK  et al. The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease. Cell Cycle 11:1918-28 (2012). PubMed: 22544329
  • Wong C  et al. Direct visualization of Bcl-2 family protein interactions using live cell fluorescent protein redistribution assays. Cell Death Dis 3:e288 (2012). PubMed: 22460384
  • Gekonge B  et al. Retinoblastoma protein induction by HIV viremia or CCR5 in monocytes exposed to HIV-1 mediates protection from activation-induced apoptosis: ex vivo and in vitro study. J Leukoc Biol 92:397-405 (2012). Human . PubMed: 22701041
  • Yee KS  et al. A RASSF1A polymorphism restricts p53/p73 activation and associates with poor survival and accelerated age of onset of soft tissue sarcoma. Cancer Res 72:2206-17 (2012). PubMed: 22389451
  • Chae HD & Broxmeyer HE SIRT1 deficiency downregulates PTEN/JNK/FOXO1 pathway to block reactive oxygen species-induced apoptosis in mouse embryonic stem cells. Stem Cells Dev 20:1277-85 (2011). PubMed: 21083429
  • Zaika E  et al. p73 protein regulates DNA damage repair. FASEB J : (2011). PubMed: 21891782
  • Gutekunst M  et al. p53 hypersensitivity is the predominant mechanism of the unique responsiveness of testicular germ cell tumor (TGCT) cells to Cisplatin. PLoS One 6:e19198 (2011). WB ; Human . PubMed: 21532991
  • Leibowitz BJ  et al. Uncoupling p53 Functions in Radiation-Induced Intestinal Damage via PUMA and p21. Mol Cancer Res 9:616-25 (2011). WB ; Mouse . PubMed: 21450905
  • Vilgelm AE  et al. Interactions of the p53 protein family in cellular stress response in gastrointestinal tumors. Mol Cancer Ther 9:693-705 (2010). WB ; Human . PubMed: 20197393
  • Yamada C  et al. RUNX3 modulates DNA damage-mediated phosphorylation of tumor suppressor p53 at Ser-15 and acts as a co-activator for p53. J Biol Chem 285:16693-703 (2010). WB ; Human . PubMed: 20353948
  • Mahmoudi S  et al. Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage. Mol Cell 33:462-71 (2009). WB . PubMed: 19250907
  • Höglund A  et al. Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine. Blood 113:4281-8 (2009). WB ; Human . PubMed: 19179467
  • Qiu W  et al. PUMA suppresses intestinal tumorigenesis in mice. Cancer Res 69:4999-5006 (2009). WB ; Mouse . PubMed: 19491259
  • Wang P  et al. PUMA is directly activated by NF-kappaB and contributes to TNF-alpha-induced apoptosis. Cell Death Differ 16:1192-202 (2009). WB . PubMed: 19444283
  • Qiu W  et al. Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis. Oncogene : (2009). WB ; Mouse . PubMed: 19966853
  • Ghosh AP  et al. The proapoptotic BH3-only, Bcl-2 family member, Puma is critical for acute ethanol-induced neuronal apoptosis. J Neuropathol Exp Neurol 68:747-56 (2009). WB ; Mouse . PubMed: 19535997
  • Zache N  et al. Mutant p53 targeting by the low molecular weight compound STIMA-1. Mol Oncol 2:70-80 (2008). PubMed: 19383329
  • Shen J  et al. PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2. Oncogene 27:6571-80 (2008). WB ; Human . PubMed: 18663359
  • Nakamizo A  et al. Phosphorylation of Thr18 and Ser20 of p53 in Ad-p53-induced apoptosis. Neuro Oncol : (2008). PubMed: 18443131
  • Wei J  et al. Interaction of Helicobacter pylori with gastric epithelial cells is mediated by the p53 protein family. Gastroenterology 134:1412-23 (2008). WB ; Human . PubMed: 18343378
  • Shi H  et al. In vitro and in vivo cytotoxic effects of PRIMA-1 on hepatocellular carcinoma cells expressing mutant p53ser249. Carcinogenesis 29:1428-34 (2008). PubMed: 18048389
  • Combaret V  et al. Effect of bortezomib on human neuroblastoma: analysis of molecular mechanisms involved in cytotoxicity. Mol Cancer 7:50 (2008). WB ; Human . PubMed: 18534018
  • Zhao R  et al. DNA damage-induced Bcl-xL deamidation is mediated by NHE-1 antiport regulated intracellular pH. PLoS Biol 5:e1 (2007). WB ; Mouse . PubMed: 17177603
  • Lee HO  et al. Regulation of DeltaNp63alpha by tumor necrosis factor-alpha in epithelial homeostasis. FEBS J 274:6511-22 (2007). PubMed: 18028447
  • McKernan DP & Cotter TG A Critical role for Bim in retinal ganglion cell death. J Neurochem 102:922-30 (2007). PubMed: 17442051
  • Abedin MJ  et al. Autophagy delays apoptotic death in breast cancer cells following DNA damage. Cell Death Differ 14:500-10 (2007). WB ; Human . PubMed: 16990848
  • Liu T  et al. Hypoxia induces p53-dependent transactivation and Fas/CD95-dependent apoptosis. Cell Death Differ 14:411-21 (2007). WB ; Human . PubMed: 16917513
  • Kieran D  et al. Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice. Proc Natl Acad Sci U S A 104:20606-11 (2007). IHC-P . PubMed: 18077368
  • Wu B  et al. p53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusion. Gut 56:645-54 (2007). IHC-P ; Mouse . PubMed: 17127703
  • Wyttenbach A & Tolkovsky AM The BH3-only protein Puma is both necessary and sufficient for neuronal apoptosis induced by DNA damage in sympathetic neurons. J Neurochem 96:1213-26 (2006). PubMed: 16478523
  • Niizuma H  et al. Bcl-2 is a key regulator for the retinoic acid-induced apoptotic cell death in neuroblastoma. Oncogene 25:5046-55 (2006). PubMed: 16568081
  • Maas K  et al. Reduced p53 in peripheral blood mononuclear cells from patients with rheumatoid arthritis is associated with loss of radiation-induced apoptosis. Arthritis Rheum 52:1047-57 (2005). PubMed: 15818671
  • Wong HK  et al. Mutually Exclusive Subsets of BH3-Only Proteins Are Activated by the p53 and c-Jun N-Terminal Kinase/c-Jun Signaling Pathways during Cortical Neuron Apoptosis Induced by Arsenite. Mol Cell Biol 25:8732-47 (2005). PubMed: 16166651
  • Ichwan SJ  et al. Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells. Oncogene : (2005). PubMed: 16247456
  • Barchéchath SD  et al. Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-alpha. J Med Chem 48:6409-22 (2005). PubMed: 16190767
  • Bykov VJ  et al. PRIMA-1(MET) synergizes with cisplatin to induce tumor cell apoptosis. Oncogene 24:3484-91 (2005). PubMed: 15735745
  • Munoz-Fontela C  et al. Resistance to viral infection of super p53 mice. Oncogene : (2005). PubMed: 15789035
  • Talos F  et al. Mitochondrially targeted p53 has tumor suppressor activities in vivo. Cancer Res 65:9971-81 (2005). PubMed: 16267022
  • Mantovani F  et al. Pin1 links the activities of c-Abl and p300 in regulating p73 function. Mol Cell 14:625-36 (2004). PubMed: 15175157
  • Jeffers JR  et al. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 4:321-8 (2003). PubMed: 14585359
  • Maclean KH  et al. c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL. Mol Cell Biol 23:7256-70 (2003). PubMed: 14517295

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