Anti-Puma gamma antibody [MM0329-6S24] (ab89298)

Overview

  • Product name
    Anti-Puma gamma antibody [MM0329-6S24]
    See all Puma gamma primary antibodies
  • Description
    Rat monoclonal [MM0329-6S24] to Puma gamma
  • Tested applications
    Suitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length Human Puma gamma protein

Properties

Applications

Our Abpromise guarantee covers the use of ab89298 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt 1/50 - 1/200.

Target

  • Function
    Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
  • Tissue specificity
    Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 1 family.
  • Developmental stage
    Expression in neutrophils occurs in the late terminal differentiation phase.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • G protein coupled receptor 109A antibody
    • G protein coupled receptor HM74a antibody
    • G protein coupled receptor Hm74b antibody
    • G-protein coupled receptor 109A antibody
    • G-protein coupled receptor HM74A antibody
    • G109A_HUMAN antibody
    • GPR 109A antibody
    • Gpr109a antibody
    • GPR109A protein antibody
    • HCA2 antibody
    • HCAR2 antibody
    • HM 74 antibody
    • HM 74a antibody
    • HM 74b antibody
    • Hm74 antibody
    • HM74a antibody
    • HM74b antibody
    • hydroxycarboxylic acid receptor 2 antibody
    • Interferon gamma inducible gene Puma g antibody
    • Niacin receptor 1 antibody
    • NIACR1 antibody
    • Nicotinic acid receptor 1 antibody
    • Nicotinic acid receptor antibody
    • Protein upregulated in macrophages by IFNG, mouse, homolog of antibody
    • Puma g antibody
    • Pumag antibody
    • rHM74b antibody
    see all

References

ab89298 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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