Overview

  • Product name
    Pumilio 2 peptide (141-155)

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-DQNRDLKQGDDDDSK
    • Amino acids
      141 to 155

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45710 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Pumilio 2 antibody (ab32894)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • FLJ36528
    • KIAA0235
    • MGC138251
    • MGC138253
    • PUM 2
    • PUM2
    • PUM2_HUMAN
    • PUMH 2
    • PUMH2
    • Pumilio (Drosphila) homolog 2
    • Pumilio homolog 2
    • Pumilio homolog 2 (Drosophila)
    • Pumilio-2
    • Pumilio2
    • PUML2
    see all
  • Function
    Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts.
  • Tissue specificity
    Expressed in male germ cells of adult testis (at protein level). Highly expressed in testis and ovary. Predominantly expressed in stem cells and germ cells. Expressed at lower level in brain, heart, kidney, liver, muscle, placenta, intestine and stomach Expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen. Expressed in all fetal tissues tested.
  • Sequence similarities
    Contains 1 PUM-HD domain.
    Contains 8 pumilio repeats.
  • Domain
    The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half doughnut. The number as well as the specific sequence of the repeats determine the specificity for target mRNAs.
  • Cellular localization
    Cytoplasm. Cytoplasmic granule. Cytoplasm > perinuclear region. The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). Colocalizes with NANOS1 and SNAPIN in the perinuclear region of germ cells.
  • Information by UniProt

References for Pumilio 2 peptide (141-155) (ab45710)

ab45710 has not yet been referenced specifically in any publications.

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