Puromycin dihydrochloride (aqueous solution, sterile-filtered) (ab146610)

Overview

  • Product name
    Puromycin dihydrochloride (aqueous solution, sterile-filtered)
  • Description
    Aminonuclease antibiotic agent. Protein biosynthesis inhibitor.
  • Biological description
    Aminonuclease antibiotic agent. Protein biosynthesis inhibitor. Induces cell cycle arrest in G2/M phase and apoptosis. Inhibits transport of proteins into mitochondria. Inhibits translation in vivo.

    Also available as a solid (ab141453).
  • Purity
    > 98%

Properties

  • Chemical name
    (2S)-2-Amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide dihydrochloride
  • Molecular weight
    544.43
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C22H29N7O5.2HCl
  • CAS Number
    58-58-2
  • PubChem identifier
    443311
  • Storage instructions
    Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview
    Supplied in water (10 mg/ml)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)NC(=O)[C@H](CC4=CC=C(C=C4)OC)N)O.Cl.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Nassirpour R  et al. Identification of Promising Urinary Microrna Biomarkers in Two Rat Models of Glomerular Injury. Toxicol Sci : (2015). Read more (PubMed: 26253709) »
  • Wan X  et al. Loss of Epithelial Membrane Protein 2 Aggravates Podocyte Injury via Upregulation of Caveolin-1. J Am Soc Nephrol : (2015). Read more (PubMed: 26264854) »
  • Price J & Verner K Puromycin inhibits protein import into mitochondria by interfering with an intramitochondrial ATP-dependent reaction. Biochim Biophys Acta 1150:89-97 (1993). Read more (PubMed: 8334141) »

See 0 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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