Anti-PVRL1 antibody [R1.302] (Phycoerythrin) (ab223561)

Overview

  • Product name
    Anti-PVRL1 antibody [R1.302] (Phycoerythrin)
    See all PVRL1 primary antibodies
  • Description
    Mouse monoclonal [R1.302] to PVRL1 (Phycoerythrin)
  • Host species
    Mouse
  • Conjugation
    Phycoerythrin. Ex: 488nm, Em: 575nm
  • Tested applications
    Suitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Tissue, cells or virus corresponding to Human PVRL1. (NIH/3T3 cells transfected with human CD111).

  • Positive control
    • Flow Cytometry: Human peripheral blood.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C. Store In the Dark.
  • Storage buffer
    Preservative: 0.0975% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • Purity
    Size exclusion
  • Purification notes
    Purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
  • Clonality
    Monoclonal
  • Clone number
    R1.302
  • Isotype
    IgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab223561 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 10µl for 106 cells.

(or 100 μl of whole blood).

Target

  • Function
    Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4.
  • Involvement in disease
    Defects in PVRL1 are the cause of ectodermal dysplasia Margarita Island type (EDMI) [MIM:225060]; also known as Zlotogora-Ogur syndrome, cleft lip/palate-ectodermal dysplasia syndrome (CLPED1) or ectodermal dysplasia 4. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDMI is an autosomal recessive syndrome characterized by the association of cleft lip/palate, ectodermal dysplasia (sparse short and dry scalp hair, sparse eyebrows and eyelashes), and partial syndactyly of the fingers and/or toes. Two thirds of the patients do not manifest oral cleft but present with abnormal teeth and nails.
    Defects in PVRL1 are the cause of non-syndromic orofacial cleft type 7 (OFC7) [MIM:225060]. Non-syndromic orofacial cleft is a common birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.
  • Sequence similarities
    Belongs to the nectin family.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Cellular localization
    Secreted and Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD111 antibody
    • CD111 antigen antibody
    • CLPED1 antibody
    • ectodermal dysplasia 4 (Margarita Island type) antibody
    • ED4 antibody
    • Herpes virus entry mediator C antibody
    • Herpesvirus entry mediator C antibody
    • Herpesvirus Ig like receptor antibody
    • Herpesvirus Ig-like receptor antibody
    • HIgR antibody
    • HveC antibody
    • MGC142031 antibody
    • Nectin 1 antibody
    • Nectin-1 antibody
    • OFC7 antibody
    • OROFACIAL CLEFT 7 antibody
    • OTTHUMP00000232093 antibody
    • OTTHUMP00000232094 antibody
    • OTTHUMP00000232095 antibody
    • Poliovirus receptor related protein 1 antibody
    • poliovirus receptor-like 1 antibody
    • Poliovirus receptor-related protein 1 antibody
    • PRR antibody
    • PRR1 antibody
    • PVRL 1 antibody
    • PVRL1 antibody
    • PVRL1_HUMAN antibody
    • PVRR antibody
    • PVRR1 antibody
    • SK-12 antibody
    see all

Images

  • Flow cytometric analysis of human peripheral blood stained for CD111 with ab223561.

References

ab223561 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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