Overview

  • Product nameAnti-PVRL4 antibody
    See all PVRL4 primary antibodies
  • Description
    Rabbit polyclonal to PVRL4
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Human
  • Immunogen

    Synthesized peptide derived from an internal region of Human PVRL4.

  • Positive control
    • extracts from NIH/3T3 cells

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • Storage bufferpH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: PBS, 50% Glycerol, 0.88% Sodium chloride
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab110387 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 55 kDa.

Target

  • FunctionSeems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with PVRL2/nectin-1. Does not act as receptor for alpha-herpesvirus entry into cells.
  • Tissue specificityPredominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma.
  • Involvement in diseaseDefects in PVRL4 are the cause of ectodermal dysplasia-syndactyly syndrome type 1 (EDSS1) [MIM:613573]. EDSS1 is a form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDSS1 is characterized by the association of hair and teeth abnormalities with cutaneous syndactyly of the hands and/or feet. Hair morphologic abnormalities include twists at irregular intervals (pilli torti) and swelling along the shafts, particularly associated with areas of breakage. Dental findings consist of abnormally widely spaced teeth, with peg-shaped and conical crowns. Patients have normal sweating.
  • Sequence similaritiesBelongs to the nectin family.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Post-translational
    modifications
    The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17/TACE.
  • Cellular localizationCell membrane. Cell junction > adherens junction. Colocalizes with MLLT4 at cadherin-based adherens junctions and Secreted. The secreted form is found in breast tumor patients.
  • Information by UniProt
  • Database links
  • Alternative names
    • DKFZp686K05193 antibody
    • EDSS1 antibody
    • Ig superfamily receptor LNIR antibody
    • Nectin 4 antibody
    • Nectin-4 antibody
    • poliovirus receptor-related 4 antibody
    • Processed poliovirus receptor-related protein 4 antibody
    • PRR4 antibody
    • pvrl4 antibody
    • PVRL4_HUMAN antibody
    see all

Anti-PVRL4 antibody images

  • All lanes : Anti-PVRL4 antibody (ab110387) at 1/500 dilution

    Lane 1 : extracts from NIH/3T3 cells
    Lane 2 : extracts from NIH/3T3 cells with blocking peptide at 10 µg

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 55 kDa

References for Anti-PVRL4 antibody (ab110387)

ab110387 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab110387.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"