Overview

  • Product nameAnti-PXR antibody
    See all PXR primary antibodies
  • Description
    Goat polyclonal to PXR
  • SpecificityThis antibody is expected to recognize all reported isoforms (NP_071285.1; NP_148934.1; NP_003880.3).
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Pig
  • Immunogen

    Synthetic peptide:

    EQFAITLKSYIECNR

    , corresponding to internal sequence amino acids 367-381 of Human PXR according to NP_003880.3; (or 406-420 of NP_071285.1; or 330-344 of NP_148934.1)

  • Positive control
    • HepG2 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab81970 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notesPeptide ELISA: antibody detection limit dilution 1:4,000.
    WB: Use at a concentration of 1 - 3 µg/ml. Predicted molecular weight: 50 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionNuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.
    • Tissue specificityExpressed in liver, colon and small intestine.
    • Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily.
      Contains 1 nuclear receptor DNA-binding domain.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • BXR antibody
      • Nr1i2 antibody
      • NR1I2_HUMAN antibody
      • Nuclear receptor subfamily 1 group I member 2 antibody
      • ONR 1 antibody
      • ONR1 antibody
      • Orphan nuclear receptor PAR 1 antibody
      • Orphan nuclear receptor PAR1 antibody
      • Orphan nuclear receptor PXR antibody
      • OTTHUMP00000215173 antibody
      • OTTHUMP00000215174 antibody
      • OTTHUMP00000215175 antibody
      • PAR 1 antibody
      • PAR 2 antibody
      • PAR antibody
      • PAR q antibody
      • PAR1 antibody
      • PAR2 antibody
      • PARq antibody
      • pregnane X nuclear receptor variant 2 antibody
      • Pregnane X receptor antibody
      • PRR antibody
      • PXR antibody
      • SAR antibody
      • Steroid and xenobiotic receptor antibody
      • SXR antibody
      see all

    Anti-PXR antibody images

    • Anti-PXR antibody (ab81970) at 1 µg/ml + HepG2 lysate in RIPA buffer at 35 µg
      Developed using the ECL technique

      Predicted band size : 50 kDa
      Observed band size : 50 kDa
      Additional bands at : 35 kDa. We are unsure as to the identity of these extra bands.

      Exposure time : 1 hour

    References for Anti-PXR antibody (ab81970)

    ab81970 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab81970.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"