Overview

  • Product nameAnti-PYGL antibody
    See all PYGL primary antibodies
  • Description
    Rabbit polyclonal to PYGL
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human PYGL (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH).

  • Positive control
    • Human liver

Properties

Applications

Our Abpromise guarantee covers the use of ab61013 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 10 µg/ml.

Target

  • FunctionPhosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
  • Involvement in diseaseDefects in PYGL are the cause of glycogen storage disease type 6 (GSD6) [MIM:232700]. A metabolic disorder characterized by mild to moderate hypoglycemia, mild ketosis, growth retardation, and prominent hepatomegaly. Heart and skeletal muscle are not affected.
  • Sequence similaritiesBelongs to the glycogen phosphorylase family.
  • Post-translational
    modifications
    Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A.
  • Information by UniProt
  • Database links
  • Alternative names
    • Glycogen phosphorylase antibody
    • Glycogen phosphorylase liver antibody
    • Glycogen phosphorylase liver form antibody
    • GSD6 antibody
    • Hers disease, glycogen storage disease type VI antibody
    • liver form antibody
    • OTTHUMP00000233649 antibody
    • OTTHUMP00000233651 antibody
    • Phosphorylase glycogen liver antibody
    • Pygl antibody
    • PYGL_HUMAN antibody
    see all

Anti-PYGL antibody images

  • ab61013 at 10µg/ml staining formalin fixed paraffin embedded liver tissue.

References for Anti-PYGL antibody (ab61013)

ab61013 has not yet been referenced specifically in any publications.

Product Wall

Unfortunately due to proprietary reasons I would not be able to provide you the exact sequence but I aligned the human sequence P06737 and the mouse sequence Q9ET01. The immunogenic peptide for antibody LS-A2283 has 80% homology between the human and t...

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