Overview

  • Product nameAnti-PYGM antibody
    See all PYGM primary antibodies
  • Description
    Rabbit polyclonal to PYGM
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human PYGM aa 800-842 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH).

  • Positive control
    • Skeletal muscle

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab60982 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 20 µg/ml.

Target

  • FunctionPhosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
  • Involvement in diseaseDefects in PYGM are the cause of glycogen storage disease type 5 (GSD5) [MIM:232600]; also known as McArdle disease. GSD5 is a metabolic disorder resulting in myopathy characterized by exercise intolerance, cramps, muscle weakness and recurrent myoglobinuria.
  • Sequence similaritiesBelongs to the glycogen phosphorylase family.
  • Post-translational
    modifications
    Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A.
  • Information by UniProt
  • Database links
  • Alternative names
    • Glycogen phosphorylase antibody
    • Glycogen phosphorylase muscle form antibody
    • muscle form antibody
    • Muscpho antibody
    • Myophosphorylase antibody
    • Phosphorylase glycogen muscle (McArdle syndrome glycogen storage disease type V) antibody
    • Pygm antibody
    • PYGM_HUMAN antibody
    see all

Anti-PYGM antibody images

  • ab60982, at a concentration of 20µg/ml, staining PYGM in formalin fixed paraffin embedded human skeletal muscle tissue sections by Immunohistochemistry.

References for Anti-PYGM antibody (ab60982)

ab60982 has not yet been referenced specifically in any publications.

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