Recombinant Anti-PYGO2 antibody [EPR2024(2)] (ab109001)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR2024(2)] to PYGO2
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
Overview
-
Product name
Anti-PYGO2 antibody [EPR2024(2)]
See all PYGO2 primary antibodies -
Description
Rabbit monoclonal [EPR2024(2)] to PYGO2 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details
Unsuitable for: Flow Cyt,ICC/IF or IP -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse -
Immunogen
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
-
Positive control
- MCF7, HeLa, Human ovary cancer, and NCCIT cell lysates.
-
General notes
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Rat: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information.
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
Storage buffer
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading...
-
Purity
Tissue culture supernatant -
Clonality
Monoclonal -
Clone number
EPR2024(2) -
Isotype
IgG -
Research areas
Associated products
-
Alternative Versions
-
Isotype control
-
Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab109001 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
1/1000 - 1/10000. Detects a band of approximately 50 kDa (predicted molecular weight: 41 kDa).
|
Notes |
---|
WB
1/1000 - 1/10000. Detects a band of approximately 50 kDa (predicted molecular weight: 41 kDa). |
Target
-
Function
Involved in signal transduction through the Wnt pathway. -
Sequence similarities
Contains 1 PHD-type zinc finger. -
Cellular localization
Nucleus. - Information by UniProt
-
Database links
- Entrez Gene: 90780 Human
- Entrez Gene: 68911 Mouse
- Omim: 606903 Human
- SwissProt: Q9BRQ0 Human
- Unigene: 533597 Human
-
Alternative names
- 1190004M21Rik antibody
- FLJ33226 antibody
- PP7910 antibody
see all
Images
Datasheets and documents
-
SDS download
-
Datasheet download
References (6)
ab109001 has been referenced in 6 publications.
- Chen Y et al. microRNA-128-3p overexpression inhibits breast cancer stem cell characteristics through suppression of Wnt signalling pathway by down-regulating NEK2. J Cell Mol Med 24:7353-7369 (2020). PubMed: 32558224
- You S et al. Abnormal expression of YEATS4 associates with poor prognosis and promotes cell proliferation of hepatic carcinoma cell by regulation the TCEA1/DDX3 axis. Am J Cancer Res 8:2076-2087 (2018). PubMed: 30416857
- Zhang S et al. Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression. Oncotarget 6:11074-86 (2015). WB, IHC . PubMed: 25871475
- Zhang S et al. Abnormal nuclear expression of Pygopus-2 in human primary hepatocellular carcinoma correlates with a poor prognosis. Histopathology 67:176-84 (2015). PubMed: 25545771
- Li B et al. Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis. PLoS One 9:e101969 (2014). WB ; Human . PubMed: 25003333
- Liu Y et al. Abnormal expression of Pygopus 2 correlates with a malignant phenotype in human lung cancer. BMC Cancer 13:346 (2013). WB, IHC . PubMed: 23865714