Vitamin B6 metabolite that acts as a coenzyme in transamination reactions by forming a Schiff-base linkage with lysine groups on aminotransferase. Also serves as a coenzyme in some decarboxylation and deamination reactions. Can modify lysyl and valyl residues in proteins. Has the ability to inhibit purinergic receptors and intracellular influx of Ca2+.
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Lowther J et al. Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivation. Mol Biosyst6:1682-93 (2010).
Read more (PubMed: 20445930) »
Neuwirth M et al. X-ray crystal structure of Saccharomyces cerevisiae Pdx1 provides insights into the oligomeric nature of PLP synthases. FEBS Lett583:2179-86 (2009).
Read more (PubMed: 19523954) »
Simon ES & Allison J Determination of pyridoxal-5'-phosphate (PLP)-bonding sites in proteins: a peptide mass fingerprinting approach based on diagnostic tandem mass spectral features of PLP-modified peptides. Rapid Commun Mass Spectrom23:3401-8 (2009).
Read more (PubMed: 19810014) »
Kim DW et al. Inactivation of brain myo-inositol monophosphate phosphatase by pyridoxal-5'-phosphate. J Biochem Mol Biol38:58-64 (2005).
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Kandzari DE et al. Reduction of myocardial ischemic injury following coronary intervention (the MC-1 to Eliminate Necrosis and Damage trial). Am J Cardiol92:660-4 (2003).
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