Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab39987 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
WB
  • Application notesPeptide ELISA: Antibody detection limit dilution 1:8,000.
    WB: Use at a concentration of 1 - 3 µg/ml. Detects a band of approximately 80 kDa. (predicted molecular weight: 86 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionProbably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeleton organization.
    • Tissue specificityExpressed in peripheral blood leukocytes, particularly in mature granulocytes and to a lesser extent in monocytes but not in lymphocytes. Detected in spleen, lung and muscle, probably as a result of leukocyte infiltration in these tissues. Not expressed in thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, liver, kidney, pancreas. Expression detected in several myeloid leukemic, colon cancer, and prostate cancer cell lines.
    • Involvement in diseaseDefects in MEFV are the cause of familial Mediterranean fever autosomal recessive (ARFMF) [MIM:249100]. ARFMF is an inherited disorder characterized by recurrent episodic fever, serosal inflammation and pain in the abdomen, chest or joints. ARFMF is frequently complicated by amyloidosis, which leads to renal failure and can be prophylactically treated with colchicine. ARFMF primarily affects ancestral ethnic groups living around the Mediterranean basin: North African Jews, Armenians, Arabs and Turks. The disease is also distributed in other populations including Greeks, Cypriots, Italians and Spanish, although at a lower prevalence.
      Defects in MEFV are the cause of familial Mediterranean fever autosomal dominant (ADFMF) [MIM:134610]. ADFMF is characterized by periodic fever, serosal inflammation and pain in the abdomen, chest or joints as seen also in the autosomal recessive form of the disease. It is associated with renal amyloidosis and characterized by colchicine unresponsiveness.
    • Sequence similaritiesContains 1 B box-type zinc finger.
      Contains 1 B30.2/SPRY domain.
      Contains 1 DAPIN domain.
    • Developmental stageFirst detected in bone marrow promyelocytes. Expression increases throughout myelocyte differentiation and peaks in the mature myelomonocytic cells.
    • Cellular localizationNucleus and Cytoplasm > cytoskeleton. Associated with microtubules and with the filamentous actin of perinuclear filaments and peripheral lamellar ruffles.
    • Information by UniProt
    • Database links
    • Alternative names
      • FMF antibody
      • Marenostrin antibody
      • Mediterranean fever antibody
      • Mediterranean fever protein antibody
      • MEF antibody
      • Mefv antibody
      • MEFV_HUMAN antibody
      • Pyrin antibody
      • TRIM20 antibody
      see all

    References for Anti-Pyrin antibody (ab39987)

    ab39987 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"