- Datasheet
- Specific References
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Overview
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Product nameAnti-QDPR antibody
See all QDPR primary antibodies -
DescriptionRabbit polyclonal to QDPR
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Host speciesRabbit
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Tested applicationsSuitable for: WB, IHC-Pmore details
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Species reactivityReacts with: Mouse, Rat, Human
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Immunogen
Recombinant fragment corresponding to Human QDPR aa 15-244.
Sequence:VYGGRG ALGSRCVQAF RARNWWVASV DVVENEEASA SIIVKMTDSF TEQADQVTAE VGKLLGEEKV DAILCVAGGW AGGNAKSKSL FKNCDLMWKQ SIWTSTISSH LATKHLKEGG LLTLAGAKAA LDGTPGMIGY GMAKGAVHQL CQSLAGKNSG MPPGAAAIAV LPVTLDTPMN RKSMPEADFS SWTPLEFLVE TFHDWITGKN RPSSGSLIQV VTTEGRTELT PAYF
Database link: P09417 -
Positive control
- Extracts from HL60, BT474, SW620, Mouse liver, mouse kidney, mouse brain and rat liver cells.
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
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Storage bufferpH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol -
Concentration information loading... -
PurityImmunogen affinity purified
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ClonalityPolyclonal
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IsotypeIgG
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Research areas
Associated products
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Compatible Secondaries
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Positive Controls
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Related Products
Applications
Our Abpromise guarantee covers the use of ab189859 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | 1/500 - 1/2000. Predicted molecular weight: 26 kDa. | |
| IHC-P | 1/50 - 1/200. |
Target
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FunctionThe product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases.
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Involvement in diseaseDefects in QDPR are the cause of BH4-deficient hyperphenylalaninemia type C (HPABH4C) [MIM:261630]; also called dihydropteridine reductase deficiency (DHPR deficiency) or hyperphenylalaninemia tetrahydrobiopterin-deficient due to DHPR deficiency or quinoid dihydropteridine reductase deficiency (QDPR deficiency). HPABH4C is a rare autosomal recessive disorder characterized by hyperphenylalaninemia and severe neurologic symptoms (malignant hyperphenylalaninemia) including axial hypotonia and truncal hypertonia, abnormal thermogenesis, and microcephaly. These signs are attributable to depletion of the neurotransmitters dopamine and serotonin, whose syntheses are controlled by tryptophan and tyrosine hydroxylases that use BH-4 as cofactor. These patients do not respond to phenylalanine-restricted diet. HPABH4C is lethal if untreated.
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Sequence similaritiesBelongs to the short-chain dehydrogenases/reductases (SDR) family.
- Information by UniProt
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Database links
- Entrez Gene: 5860 Human
- Entrez Gene: 110391 Mouse
- Entrez Gene: 64192 Rat
- Omim: 612676 Human
- SwissProt: P09417 Human
- SwissProt: Q8BVI4 Mouse
- SwissProt: P11348 Rat
- Unigene: 75438 Human
see all -
Alternative names
- 6,7 dihydropteridine reductase antibody
- DHPR antibody
- DHPR_HUMAN antibody
see all
Images
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Western blot - Anti-QDPR antibody (ab189859)All lanes : Anti-QDPR antibody (ab189859) at 1/500 dilution
Lane 1 : HL60 cell extract
Lane 2 : BT474 cell extract
Lane 3 : SW620 cell extract
Lane 4 : Mouse liver cell extract
Lane 5 : Mouse kidney cell extract
Lane 6 : Mouse brain cell extract
Lane 7 : Rat liver cell extract
Predicted band size: 26 kDa
References
ab189859 has not yet been referenced specifically in any publications.
Customer reviews and Q&As
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"