Overview

  • Product nameAnti-QK1 antibody
    See all QK1 primary antibodies
  • Description
    Rabbit polyclonal to QK1
  • Tested applicationsSuitable for: WB, IPmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide from mouse QK1.

  • Positive control
    • Glial cells, astrocytes and oligodendrocytes.

Properties

Applications

Our Abpromise guarantee covers the use of ab78518 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IP
  • Application notesIP: Use 1 - 2µl.
    WB: 1/500 - 1/1000. Predicted molecular weight: 38 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionRNA-binding protein that plays a central role in myelinization (PubMed:16641098). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077). In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098). Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor.
    • Tissue specificityExpressed in the frontal cortex of brain. Down-regulated in the brain of schizophrenic patients.
    • Sequence similaritiesContains 1 KH domain.
    • DomainThe KH domain and the Qua2 region are involved in RNA binding.
    • Post-translational
      modifications
      Methylated by PRMT1.
      Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA.
    • Cellular localizationNucleus. Cytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • DKFZp586I0923 antibody
      • HKQ antibody
      • Homolog of mouse quaking QKI KH domain RNA binding protein antibody
      • Hqk antibody
      • HQK1 antibody
      • HqkI antibody
      • OTTHUMP00000017581 antibody
      • OTTHUMP00000017582 antibody
      • OTTHUMP00000017583 antibody
      • Protein quaking antibody
      • QK antibody
      • QK1 antibody
      • QK3 antibody
      • QKI antibody
      • QKI_HUMAN antibody
      • QKI1 antibody
      • Quaking homolog antibody
      • Quaking homolog KH domain RNA binding antibody
      • Quaking homolog KH domain RNA binding mouse antibody
      • Quaking isoform 1 antibody
      • Quaking protein antibody
      • RNA binding protein HQK antibody
      see all

    References for Anti-QK1 antibody (ab78518)

    ab78518 has not yet been referenced specifically in any publications.

    Product Wall

    You are very welcome.



    . Please let me know if you have any questions or there are other ways that Abcam may help you meet your research goals.

    Thank you for contacting us.Jeremy is out of the office today, but I’d be happy to help with your inquiry. My name is Keith.

    In regards to the immunogen sequence which you have requested. Ab78130 is specific for QK1 isoform 1, known ...

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    Thanks for your enquiry.

    I have passed your enquiry regarding the immunogen sequence for ab78518 on to the lab. I will forward you any information I receive.

    The concentration of these 3 antibodies has not been determined. ab78518 a...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"