Overview

  • Product name
  • Description
    Rabbit polyclonal to QPCT
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Sheep, Rabbit, Guinea pig, Cow
  • Immunogen

    Synthetic peptide within residues: SRHLAAKMAS TPHPPGARGT SQLHGMDLLV LLDLIGAPNP TFPNFFPNSA , corresponding to internal sequence amino acids 216-265 of Human QPCT (NP_036545)

  • Positive control
    • Human fetal muscle lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab85183 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 38 kDa (predicted molecular weight: 38 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function
    Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.
  • Sequence similarities
    Belongs to the glutaminyl-peptide cyclotransferase family.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • 5730422A13Rik antibody
    • EC antibody
    • GCT antibody
    • Glutaminyl cyclase antibody
    • Glutaminyl peptide cyclotransferase antibody
    • Glutaminyl tRNA cyclotransferase antibody
    • Glutaminyl-peptide cyclotransferase antibody
    • Glutaminyl-tRNA cyclotransferase antibody
    • Glutamyl cyclase antibody
    • QC antibody
    • qpct antibody
    • QPCT_HUMAN antibody
    • sQC antibody
    see all

Images

  • Anti-QPCT antibody (ab85183) at 1 µg/ml + Human fetal muscle lysate at 10 µg

    Secondary
    anti-Rabbit IgG HRP at 1/50000 dilution

    Predicted band size : 38 kDa
    Observed band size : 38 kDa

References

ab85183 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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