Overview

  • Product name
  • Description
    Rabbit polyclonal to QSOX2
  • Tested applications
    Suitable for: IHC-P, WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    internal sequence amino acids 504-633 of Human QSOX2.

  • Positive control
    • Human epididymis tissue; RT4 and U-251 MG cell lysate; Human Plasma.

Properties

Applications

Our Abpromise guarantee covers the use of ab121376 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/250 - 1/500.
ICC/IF Use a concentration of 1 - 4 µg/ml.

Recommend PFA Fixation and Triton X-100 treatment

Target

  • Function
    Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis.
  • Tissue specificity
    Expressed in pancreas, brain, placenta, kidney, heart and fetal tissues. Weakly expressed in lung, liver and skeletal muscles.
  • Sequence similarities
    Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
    Contains 1 ERV/ALR sulfhydryl oxidase domain.
    Contains 1 thioredoxin domain.
  • Cellular localization
    Membrane. Secreted. Cell membrane. Nucleus membrane. Seems to be predominantly targeted to the nuclear and outer plasma membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • DKFZp762A2013 antibody
    • Neuroblastoma-derived sulfhydryl oxidase antibody
    • QSCN6L1 antibody
    • QSOX2 antibody
    • QSOX2_HUMAN antibody
    • Quiescin Q6 like 1 antibody
    • Quiescin Q6 sulfhydryl oxidase 2 antibody
    • Quiescin Q6-like protein 1 antibody
    • SOXN antibody
    • Sulfhydryl oxidase 2 antibody
    see all

Images

  • Immunofluorescent staining of Human cell line U-2 OS shows positivity in golgi apparatus and vesicles. Recommended concentration of ab121376 1-4 µg/ml. Cells treated with PFA/Triton X-100.
  • ab121376 at 1/75 dilution staining QSOX2 in paraffin-embedded Human epididymis tissue by Immunohistochemistry.
  • All lanes : Anti-QSOX2 antibody (ab121376) at 1/250 dilution

    Lane 1 : Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11
    Lane 2 : RT-4 cell lysate.
    Lane 3 : U-251 MG cell lysate.
    Lane 4 : Human Plasma
    Lane 5 : Human Liver lysate.
    Lane 6 : Human Tonsil lysate.

    Developed using the ECL technique

References

ab121376 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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