Biological descriptionNon-selective phospholipase A2 inhibitor (PLA2). IC50 = 200 μM for bovine brain cPLA2. Neuroprotective properties. Centrally active upon intraperitoneal administration.
This product is reported to be light sensitive
Chemical nameN4-(6-Chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-1,4-pentanediamine dihydrochloride
Storage instructionsStore at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM (with warming)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
References for Quinacrine dihydrochloride (ab120749)
This product has been referenced in:
Ong WY et al. Quinacrine abolishes increases in cytoplasmic phospholipase A2 mRNA levels in the rat hippocampus after kainate-induced neuronal injury. Exp Brain Res148:521-4 (2003).
Read more (PubMed: 12582837) »
Lu XR et al. Differential effects of calcium-dependent and calcium-independent phospholipase A(2) inhibitors on kainate-induced neuronal injury in rat hippocampal slices. Free Radic Biol Med30:1263-73 (2001).
Read more (PubMed: 11368924) »