Overview

  • Product nameQuinacrine dihydrochloride
  • Description
    Non-selective phospholipase A2 inhibitor
  • Alternative names
    • Atebrine
    • Mepacrine
  • Biological descriptionNon-selective phospholipase A2 inhibitor (PLA2). IC50 = 200 μM for bovine brain cPLA2. Neuroprotective properties. Centrally active upon intraperitoneal administration.
  • Purity> 98%
  • General notes

    This product is reported to be light sensitive

Properties

  • Chemical nameN4-(6-Chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-1,4-pentanediamine dihydrochloride
  • Molecular weight472.88
  • Chemical structureChemical Structure
  • Molecular formulaC23H30ClN3O.2HCl
  • CAS Number69-05-6
  • Storage instructionsStore at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overviewSoluble in water to 100 mM (with warming)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

  • Research areas

    References for Quinacrine dihydrochloride (ab120749)

    This product has been referenced in:
    • Ong WY  et al. Quinacrine abolishes increases in cytoplasmic phospholipase A2 mRNA levels in the rat hippocampus after kainate-induced neuronal injury. Exp Brain Res 148:521-4 (2003). Read more (PubMed: 12582837) »
    • Lu XR  et al. Differential effects of calcium-dependent and calcium-independent phospholipase A(2) inhibitors on kainate-induced neuronal injury in rat hippocampal slices. Free Radic Biol Med 30:1263-73 (2001). Read more (PubMed: 11368924) »

    See 0 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"