Selective full 5-HT1A receptor agonist. More active enantiomer of 8-OH-DPAT. Displays greater efficacy at 5-HT1A. Also displays moderate affinity at 5-HT7. Inhibits amphetamine induced dopamine release.
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in water to 20 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Stevens KE et al. The 5-HT(1A) receptor active compounds (R)-8-OH-DPAT and (S)-UH-301 modulate auditory evoked EEG responses in rats. Amino Acids31:365-75 (2006).
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Ichikawa J & Meltzer HY R(+)-8-OH-DPAT, a serotonin(1A) receptor agonist, potentiated S(-)-sulpiride-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens but not striatum. J Pharmacol Exp Ther291:1227-32 (1999).
Read more (PubMed: 10565846) »
Hadrava V et al. Partial agonistic activity of R- and S-enantiomers of 8-OH-DPAT at 5-HT1A receptors. J Psychiatry Neurosci21:101-8 (1996).
Read more (PubMed: 8820175) »