(R)-(+)-8-Hydroxy-DPAT hydrobromide (8-Hydroxy DPAT) (ab120507)

Overview

  • Product name
    (R)-(+)-8-Hydroxy-DPAT hydrobromide (8-Hydroxy DPAT)
  • Description
    Selective full 5-HT1A receptor agonist
  • Alternative names
    • 8-Hydroxy DPAT
  • Biological description
    Selective full 5-HT1A receptor agonist. More active enantiomer of 8-OH-DPAT. Displays greater efficacy at 5-HT1A. Also displays moderate affinity at 5-HT7. Inhibits amphetamine induced dopamine release.
  • Purity
    > 98%

Properties

Associated products

References

This product has been referenced in:
  • Stevens KE  et al. The 5-HT(1A) receptor active compounds (R)-8-OH-DPAT and (S)-UH-301 modulate auditory evoked EEG responses in rats. Amino Acids 31:365-75 (2006). Read more (PubMed: 16868646) »
  • Ichikawa J & Meltzer HY R(+)-8-OH-DPAT, a serotonin(1A) receptor agonist, potentiated S(-)-sulpiride-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens but not striatum. J Pharmacol Exp Ther 291:1227-32 (1999). Read more (PubMed: 10565846) »
  • Hadrava V  et al. Partial agonistic activity of R- and S-enantiomers of 8-OH-DPAT at 5-HT1A receptors. J Psychiatry Neurosci 21:101-8 (1996). Read more (PubMed: 8820175) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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