R-(-)-α-Methylhistamine dihydrobromide (ab120774)

Overview

  • Product nameR-(-)-α-Methylhistamine dihydrobromide
  • Description
    Highly potent, selective H3 receptor agonist
  • Biological descriptionHighly potent, selective H3 receptor agonist (Kd = 50 nM). Induces H4-mediated eosinophil shape change (EC50 = 66 nM). Inhibits H3-mediated histamine synthesis and release in the CNS. Active in vivo.
  • Purity> 99%

Properties

  • Chemical name1-(1H-Imidazol-5-yl)propan-2-amine dihydrobromide
  • Molecular weight287.00
  • Chemical structureChemical Structure
  • Molecular formulaC6H11N3.2HBr
  • CAS Number75614-87-8
  • PubChem identifier206868
  • Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overviewSoluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESCC(CC1=CN=CN1)N.Br.Br
  • Source

    Synthetic

  • Research areas

    References for R-(-)-α-Methylhistamine dihydrobromide (ab120774)

    This product has been referenced in:
    • Francis H  et al. H3 histamine receptor-mediated activation of protein kinase Calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo. Mol Cancer Res 7:1704-13 (2009). Read more (PubMed: 19825989) »
    • Francis H  et al. H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA/ERK1/2/ELK-1 pathway. Lab Invest 87:473-87 (2007). Read more (PubMed: 17334413) »
    • Oishi R  et al. Effects of the histamine H3-agonist (R)-alpha-methylhistamine and the antagonist thioperamide on histamine metabolism in the mouse and rat brain. J Neurochem 52:1388-92 (1989). Read more (PubMed: 2540269) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"